摘要
Abstract
Objective:To explore the effect of blastocyst diameter on pregnancy outcomes of single frozen-thawed blastocyst transfer(SFBT)cycles.
Methods:A total of 1 337 cycles of SFBT in Reproductive Center of The Shanghai Towako Hospital from January 2017 to July 2023 were retrospectively analyzed,and the blastocysts were divided into four groups according to their diameters as 160 μm group,161-179 μm group,180-199 μm group,and ≥200 μm group.According to the Gardner criteria and Chinese expert consensus,they were further divided into three subgroups:high-quality blastocyst group(AA/AB/BA/BB),ordinary blastocyst group(AC/CA/BC/CB)and low-quality blastocyst group(CC).According to the blastocyst developmental day,the blastocysts were further divided into two subgroups as the D5 group and the D6 group.The clinical pregnancy rates and live birth rates were compared among four blastocyst diameter groups,as well as among different blastocyst diameter subgroups under the same blastocyst quality and blastocyst developmental days.
Results:In 1 337 SFBT cycles included,a clinical pregnancy rate of 54.45％(728/1 337)and a live birth rate of 42.41％(567/1 337)were found.The clinical pregnancy rate of the ≥200 μm group was significantly higher than those of the other three groups(P＜0.05),and that of the 180-199 μm group was significantly higher when compared with the 160 μm group(P＜0.05).The live birth rate of the ≥200 μm group was significantly higher than those of the 160 μm group and the 161-179 μm group(P＜0.05),and that of the 180-199 μm group was significantly higher when compared with the 160 μm group(P＜0.05).According to blastocyst quality,the clinical pregnancy rates and live birth rates of high-quality and low-quality blastocysts showed a gradually increasing trend as the blastocyst diameters increased,but showing no significant differences(P＞0.05).In the ordinary blastocyst group,the clinical pregnancy and live birth rates of the ≥200 μm subgroup were significantly higher than those of the other three subgroups(P＜0.05),but the latter had no significant differences(P＞0.05).In the D5 group,the clinical pregnancy and live birth rates of the ≥200 μm group were significantly higher than those of the other three subgroups(P＜0.05),and the clinical pregnancy and live birth rates of the 180-199 μm subgroup were significantly higher than those of the 160 μm subgroup(P＜0.05).In the D6 group,the clinical pregnancy rate of the≥200 μm subgroup was significantly higher than that of the 161-179 μm subgroup(P＜0.05),and there were no significant differences among the other subgroup(P＞0.05).The live birth rate of the 180-199 μm subgroup was significantly higher than that of the 161-179 μm subgroup(P＜0.05),and there were no significant differences among the other subgroup(P＞0.05).
Conclusions:In SFBT cycles,regardless of classified by blastocyst quality or the developmental day,both clinical pregnancy rate and live birth rate showed an increasing trend with blastocyst diameters increased,which significantly affected pregnancy outcomes of ordinary blastocysts and those on different developmental days.During blastocyst transfer,when other conditions are similar,priority should be given to transferring blastocysts with larger diameter.关键词
单囊胚移植/囊胚直径/囊胚级别/囊胚发育天数/临床妊娠率/活产率Key words
Single blastocyst transfer/Blastocyst diameter/Blastocyst grade/Blastocyst developmental day/Clinical pregnancy rate/Live birth rate分类
临床医学
