生殖医学杂志2025，Vol.34Issue(3)：398-404,7.DOI:10.3969/j.issn.1004-3845.2025.03.020
母胎交互调控囊胚激活机制的研究进展
Research progress of regulating the blastocyst activation with maternal-fetal communication
摘要
Abstract
The intimate maternal-fetal communication between the endometrium and blastocyst serves as a crucial prerequisite for successful embryo implantation.During the embryo implantation process,the blastocyst and endometrium develop synergistically,regulating the release and uptake of extracellular vesicles,the activity of canonical Wnt signaling pathway,etc.,and the specific expression of molecules such as integrins,L-selectins,and heparin-binding epidermal growth factors(HB-EGF)and so on.Through these various mechanisms,they achieve precise and orchestrated communication.Their interaction enhances the blastocyst's cellular activity,metabolism and proliferation,thereby controls its activation and facilitates the development of adhesion,invasion,and implantation capabilities.Disrupted maternal-fetal communication can negatively impact blastocyst activation,so it is a significant factor contributing to failed embryo implantation.This review delves into the molecular mechanisms underlying maternal-fetal communication in regulating blastocyst activation,offering a fresh perspective on the pathological processes involved in recurrent implantation failure(RIF).Additionally,it proposes potential therapeutic approaches for improving outcomes in clinical IVF-ET procedures.关键词
囊胚激活/母胎交互/胚胎植入/子宫内膜容受性/细胞外囊泡Key words
Blastocyst activation/Maternal-fetal communication/Endometrial receptivity/Extracellular vesicles分类
医药卫生引用本文复制引用
李凯茜,赵晓丽,徐佳淇,江楠,夏天..母胎交互调控囊胚激活机制的研究进展[J].生殖医学杂志,2025,34(3):398-404,7.基金项目
国家自然科学基金(82205172) （82205172）
