妇儿健康导刊2025，Vol.4Issue(5)：27-31,36,6.DOI:10.3969/j.issn.2097-115X.2025.05.003
孕妇尿液游离DNA在胎儿染色体异常检测中的研究进展
Research progress of cell-free DNA in pregnant women's urine in detecting fetal chromosome abnormalities
赵佳 1宋硕1
作者信息
- 1. 深圳市第四人民医院科教部,广东 深圳 518118
- 折叠
摘要
Abstract
Cell-free DNA from pregnant women's urine has shown great potential as a non-invasive biomarker for the detection of fetal chromosomal abnormalities.One of the mechanisms of plasma clearance of fetal cell-free DNA is by the kidneys via urine.The development of a non-invasive test based on urine cell-free DNA to identify fetal chromosome aneuploidy through high-throughput sequencing technology promises to be a safer and more convenient clinical diagnostic specimen when compared with existing peripheral blood non-invasive prenatal testing technologies.This article reviews the progress of the application of cell-free DNA in pregnant women's urine in the detection of fetal chromosomal abnormalities.关键词
孕妇尿液/游离DNA/胎儿染色体异常/高通量测序Key words
Pregnant women's urine/Cell-free DNA/Fetal chromosome abnormality/High-throughput sequencing分类
医药卫生引用本文复制引用
赵佳,宋硕..孕妇尿液游离DNA在胎儿染色体异常检测中的研究进展[J].妇儿健康导刊,2025,4(5):27-31,36,6.
