现代妇产科进展2025，Vol.34Issue(3)：178-184,7.DOI:10.13283/j.cnki.xdfckjz.2025.03.003
早期子宫内膜癌2023年国际妇产科联盟新分期的应用与验证
Application and verification of the International Federation of Gynecology and Obstetrics 2023 staging in early-stage endometrial cancer:a retrospective study
摘要
Abstract
Objective:To explore the changes of the staging in early stage endometrial cancer by using FIGO 2023 and FIGO 2009 staging system,and to compare the prognosis pre-dictive value of different staging system and 2021 European Society of Gynecological Oncology(ESGO)risk group.Methods:Patients with stage Ⅰ～Ⅱ endometrial cancer who underwent surgical treatment were retrospectively enrolled,and FIGO 2023 restaging was performed based on molecular classification and pathologic features.The survival rate of the patients was calcu-lated,and the Akaike information criterion(AIC)values and Harrell's concordance index(C-index)were compared.A higher C-index score and a lower AIC value indicated a more accurate model.Results:A total of 281 patients were included,and 48 cases(17.1%)showed upgrade in stage(including sub-stage)after applying FIGO 2023 staging.After correction of staging ac-cording to molecular typing,9 cases(3.2%)showed stage downgrade due to POLE mutant subtype,and 7 cases(2.4%)upshifted due to p53 aberrant subtype.5-year relapse-free sur-vival(RFS)in stage Ⅰ patients was higher in FIGO 2023m staging(96.8%)than in 2009 staging(91.6%),and 5-year RFS in stage Ⅱ patients was lower in FIGO 2023m staging(64.9%)than those in 2009 staging(85.7%).FIGO 2023m staging had the discriminatory ability and accuracy with the low AIC value and the high C-index.Conclusion:FIGO 2023 staging with molecular classification is a good predictor of survival with higher prognostic dis-criminatory ability.关键词
子宫内膜癌/国际妇产科联盟分期/分子分型/预后Key words
Endometrial carcinoma/International Federation of Gynecology and Ob-stetrics stage/Molecular classification/Prognosis分类
临床医学引用本文复制引用
卢云,郝圆圆,脱淑梅,王玥元,赵洁..早期子宫内膜癌2023年国际妇产科联盟新分期的应用与验证[J].现代妇产科进展,2025,34(3):178-184,7.基金项目
兰州市科技计划项目(No:22-5-88) （No:22-5-88）
