现代妇产科进展2025，Vol.34Issue(3)：185-190,195,7.DOI:10.13283/j.cnki.xdfckjz.2025.03.031
KELIM及BRCA突变状态在预测晚期高级别浆液性卵巢癌预后中的价值
Evaluating the prognostic value of KELIM and BRCA mutation status in advanced high-grade serous ovarian cancer
摘要
Abstract
Objective:To explore the prognostic value of the modeled carbohydrate an-tigen 125 elimination rate constant K(KELIM)and BRCA mutation status in patients with ad-vanced high-grade serous ovarian cancer(HGSOC)who have undergone primary debulking surgery(PDS).Methods:A retrospective analysis of clinical information and follow-up data from 212 patients with advanced high-grade serous ovarian cancer(HGSOC)who underwent primary debulking surgery(PDS)at the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)from January 2018 to December 2022.To cal-culate the KELIM values of these patients and analyze their prognostic value,as well as to ex-plore the combined prognostic value of KELIM and BRCA1/2 mutation status.Result:Among the 212 patients with advanced HGSOC,102(48.1%)had a KELIM value<1,and 110(51.9%)had a KELIM value≥1.The number of chemotherapy cycles and the proportion of patients receiving antiangiogenic agents were higher in the KELIM<1 group compared to the KELIM≥1 group(P=0.001).Logistic regression analysis indicated that the absence of visible residual disease(P=0.005),KELIM≥1(P=0.003),and BRCA mutations(P=0.007)were significant predictors of platinum resistance.Survival analysis showed that the absence of visible residual disease,BRCA mutations,and KELIM≥1 were independent predictors of progression-free survival(PFS)(P<0.05).FIGO stage Ⅲ(HR=0.420,95%CI 0.215～0.821)and KELIM≥1(HR=0.460,95%CI 0.234～0.908)were independent factors affecting overall survival(OS)in patients with advanced HGSOC.Subgroup analysis revealed that KELIM had significant prognostic value for PFS and OS in BRCA mutation carriers,whereas no significant differences were observed in BRCA wild-type patients.Conclusions:KELIM value can serve as one of the indicators for assessing the prognosis of patients with advanced HGSOC,particularly in those with BRCA gene mutations.关键词
高级别浆液性卵巢癌/糖类抗原125/CA125消除速率常数KKey words
High-grade serous ovarian cancer/Carbohydrate Antigen 125/CA125 elimination rate constant K分类
临床医学引用本文复制引用
江珊,朱靖,王莹莹,邢娟,申震,周颖..KELIM及BRCA突变状态在预测晚期高级别浆液性卵巢癌预后中的价值[J].现代妇产科进展,2025,34(3):185-190,195,7.基金项目
国家自然科学基金(No:82303588,82473382) （No:82303588,82473382）
安徽省重点研发项目(No:2022e07020013) （No:2022e07020013）
安徽省教育厅自然科学基金(No:2022AH051255) （No:2022AH051255）
2020年中国科学技术大学附属第一医院领先技术项目(No:2020LXJS-05) （No:2020LXJS-05）
北京科创基金(No:KC2021-JX-0186-143) （No:KC2021-JX-0186-143）
