现代妇产科进展2025，Vol.34Issue(3)：207-210,216,5.DOI:10.13283/j.cnki.xdfckjz.2025.03.005
冻融周期单胚胎移植后单卵双胎的相关因素分析
Analysis of factors associated with monozygotic twin after single Frozen-thaw embryo transfer
摘要
Abstract
Objective:To analyze the incidence and the factors relevant to monozygotic twins(MZT)pregnancy conceived by assisted reproductive technology(ART)after frozen-thaw single embryo transfer.Methods:A retrospective analysis was conducted on the basic data of 24585 patients who got pregnancy after frozen-thawed single embryo transfer treatment at the Reproductive Medicine Center of Peking University Third Hospital between January 2010 and June 2023.Among these,409 cases were monozygotic twin(MZT)pregnancies.The MZT group was matched with a singleton group(1:4 ratio)based on the transfer date,resulting in 1636 singleton cases.The study analyzed the basic characteristics,treatment protocols,and laboratory procedures in both groups to explore their association with the occurrence of MZT.Results:409 cases were MZT pregnancies(1.7%,409/24585).In the univariate analysis,there was a sta-tistically significant difference in maternal body mass index(BMI)between the MZT group and the singleton pregnancy group[22.00(20.10～24.70)vs 21.51(19.60～24.22),P=0.007].The regression analysis revealed that maternal BMI was significantly associated with the occurrence of MZT(OR=0.928,95%CI:0.904～0.954).However,no significant differ-ences were observed between the two groups in terms of treatment protocols,fertilization meth-ods,assisted hatching(AH),preimplantation genetic testing(PGT),or the type of embryo transfer.Conclusion:The occurrence of MZT after frozen-thawed single embryo transfer is not significantly associated with medical procedures,including treatment protocols,intracytoplasmic sperm injection(ICSI),AH,PGT,or blastocyst culture.关键词
辅助生殖技术/体外受精/卵细胞浆内单精子注射/单卵双胎/冻融胚胎移植/辅助孵化Key words
Assisted reproductive technology/Assisted reproductive technology/Intra-cytoplasmic sperm injection/Monozygotic twin pregnancy/Frozen-thawed embryos transfer/As-sisted hatching分类
临床医学引用本文复制引用
张珺,赵捷,黄铄..冻融周期单胚胎移植后单卵双胎的相关因素分析[J].现代妇产科进展,2025,34(3):207-210,216,5.基金项目
国家自然科学基金(No:82271863) （No:82271863）
北京大学第三医院院临床重点项目(No:BYSYZD2023007) （No:BYSYZD2023007）
