新医学2025，Vol.56Issue(2)：139-147,9.DOI:10.12464/j.issn.0253-9802.2024-0420
柴胡疏肝散治疗桥本甲状腺炎效果的meta分析
Meta-analysis of Chaihu Shugan Powder in the treatment of Hashimoto's thyroiditis
摘要
Abstract
Objective To evaluate the efficacy and safety of Chaihu Shugan Powder in the treatment of Hashimoto's thyroiditis.Methods Randomized controlled trials of Chaihu Shugan Powder in the treatment of Hashimoto's thyroiditis were searched from China Knowledge Network,VIP Database,Wanfang Database,China Biomedical Literature Database,PubMed,Embase and Cochrane Library from date of database inception until October,2024.Meta-analysis was performed using RevMan 5.3.Results A total of 9 literatures were included,involving 671 patients with Hashimoto's thyroiditis.Meta-analysis showed that Chaihu Shugan Powder could improve the clinical effectiveness rate of Hashimoto's thyroiditis[RR(95%CI)=1.21(1.13,1.30)],reduce the levels of thyroid peroxidase antibody[TPO-Ab,SMD(95%CI)=-1.61(-2.28,-0.94)],decrease the level of thyroglobulin antibody[TgAb,SMD(95%CI)=-1.28(-1.70,-0.86)],reduce traditional Chinese medicine syndrome score[MD(95%CI)=-6.15(-6.69,-5.61)],improve function of thyroid[TSH:MD(95%CI)=-0.83(-1.57,-0.09),FT3:MD(95%CI)=0.64(0.12,1.16),FT4:MD(95%CI)=2.31(0.70,3.92)]and reduce the level of inflammatory factor interleukin-23[IL-23,SMD(95%CI)=-1.92(-2.29,-1.54)].In addition,compared with the control group,Chaihu Shugan Powder did not increase the incidence of adverse reactions.Conclusion Chaihu Shugan Powder is an effective and safe treatment for Hashimoto's thyroiditis,but further research and verification is needed.关键词
桥本甲状腺炎/柴胡疏肝散/中医药/Meta分析Key words
Hashimoto's thyroiditis/Chaihu Shugan Powder/Traditional Chinese medicine/Meta-analysis引用本文复制引用
邓洪枭,刘岩松,汪亚娅,司新颖,丁治国..柴胡疏肝散治疗桥本甲状腺炎效果的meta分析[J].新医学,2025,56(2):139-147,9.基金项目
陕西省中医药管理局双链融合项目(2022-SLRH-LG-005) （2022-SLRH-LG-005）
陕西省科技厅重点研发计划(2023-ZDLSF-56) （2023-ZDLSF-56）
陕西省自然科学基础研究计划项目(2024JC-YBMS-676) （2024JC-YBMS-676）
