新医学2025，Vol.56Issue(2)：168-174,7.DOI:10.12464/j.issn.0253-9802.2024-0453
颈部淋巴结细针穿刺洗脱液中甲状腺球蛋白检测的应用现状
Application of thyroglobulin detection in fine-needle aspiration washout fluid from cervical lymph node
摘要
Abstract
Differentiated thyroid carcinoma(DTC)is the most common type of thyroid malignancy,with a high incidence of regional lymph node metastasis.Accurate diagnosis of lymph node metastasis is crucial for determining appropriate treatment strategies.Fine-needle aspiration(FNA)is an important method for evaluating the nature of thyroid nodules and lymph node metastasis.In recent years,the detection of thyroglobulin(Tg)levels in FNA washout fluid has received widespread attention as a supplementary tool for cytological examination.FNA-Tg can increase the detection rate of cytology-negative lymph node metastasis,with high sensitivity and specificity.Combined with other diagnostic methods such as serology examination and imaging analysis,it can further enhance diagnostic value.However,there is currently a lack of standardized procedures for FNA-Tg operation and specimen handling.The methodological and interpretative standards for quantitative Tg have not been established.And it is still controversial whether various factors,such as thyroid hormone replacement therapy,Tg autoantibodies,and residual thyroid tissue,affect the results of FNA-Tg.This article reviews the current status and dilemma of the application of FNA-Tg testing in neck lymph nodes to provide a reference for the clinical application of FNA-Tg testing in the diagnosis of lymph node metastasis in DTC.关键词
细针穿刺/洗脱液/甲状腺球蛋白/甲状腺癌/淋巴结/超声Key words
Fine needle aspiration/Washout/Thyroglobulin/Thyroid cancer/Lymph node/Ultrasound引用本文复制引用
曾庆欣,钟海烽..颈部淋巴结细针穿刺洗脱液中甲状腺球蛋白检测的应用现状[J].新医学,2025,56(2):168-174,7.基金项目
梅州市社会发展科技计划项目(2024C0301072) （2024C0301072）
梅州市人民医院科研培育项目(PY-C2020032) （PY-C2020032）
