中国肺癌杂志2025，Vol.28Issue(2)：138-145,8.DOI:10.3779/j.issn.1009-3419.2025.101.03
肿瘤细胞与神经信号在神经内分泌癌转移中的串扰作用:基于通讯劫持的视角
Crosstalk between Tumor Cells and Neural Signals in Neuroendocrine Carcinoma Metastasis:Communication Hijacking Based Perspective
摘要
Abstract
Neuroendocrine carcinoma(NEC)represents a category of malignant tumors originating from neuroen-docrine cells.Given that NEC cells exhibit characteristics of both neural and endocrine cells,they can hijack neuronal signaling pathways and dynamically regulate the expression of neuronal lineage markers during tumor metastasis,thereby constructing a microenvironment conducive to tumor growth and metastasis.Conversely,alterations in the tumor microenvironment can enhance the interactions between neurons and tumor cells,ultimately synergistically promoting the metastasis of NEC.This review highlights recent advancements in the field of cancer neuroscience,uncovering neuronal lineage markers in NEC that facilitate tumor dissemination through mediating crosstalk,bidirectional communication,and synergistic interactions between tumor cells and the nervous system.Consequently,the latest findings in tumor neuroscience have enriched our understanding of the biological mechanisms underlying tumor metastasis,opening new research avenues for a deeper comprehension of the complex biological processes involved in tumor metastasis,particularly brain metastasis.This review provides a comprehensive review of the crosstalk between tumor cells and neural signaling in the metastasis of NEC.关键词
癌症神经科学/肿瘤转移/神经内分泌癌/串扰作用/通讯劫持Key words
Cancer neuroscience/Tumor metastasis/Neuroendocrine carcinoma/Crosstalk effect/Communica-tion hijacking引用本文复制引用
宋淑萍,王心怡,周锶琪,成旭晨,林潍轩,王永炫,孙艳芹..肿瘤细胞与神经信号在神经内分泌癌转移中的串扰作用:基于通讯劫持的视角[J].中国肺癌杂志,2025,28(2):138-145,8.基金项目
This paper was supported by the grants from National Natural Science Foundation of China(No.81702285)(to Yanqin 本文受国家自然科学基金项目(No.81702285)、广东省基础与应用基础研究基金项目(No.2022A1515012190)、湛江市科技发展专项资金竞争性分配项目(No.2022A01018)、大学生创新创业训练计划项目(No.S202410571113)和广东医科大学松山湖医工融合创新中心专项项目(No.4SG22312P)资助SUN),Guangdong Basic and Applied Basic Research Foundation(No.2022A1515012190)(to Yanqin SUN),Zhanjiang Sci-ence,Technology Development Special Fund Competitive Allocation Project(No.2022A01018)(to Yanqin SUN),National Innovation and Entrepreneurship Training Program for College Students(No.S202410571113)(to Weixuan LIN)and Guang-dong Medical University Songshan Lake Medical Integration Innovation Center Special Project(No.4SG22312P)(to Yanqin SUN). （No.81702285）
