中国肺癌杂志2025，Vol.28Issue(2)：155-164,10.DOI:10.3779/j.issn.1009-3419.2025.102.07
上皮间充质转化:肺癌侵袭转移及耐药性的生物学基础与临床展望
Epithelial-mesenchymal Transition:Biological Basis and Clinical Prospects of Lung Cancer Invasion,Metastasis,and Drug Resistance
摘要
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide,characterized by high incidence and mortality rates.The primary reasons for treatment failure in lung cancer patients are tumor invasion and drug resistance,particularly resistance to chemotherapeutic agents and epidermal growth factor receptor(EGFR)mutant targeted therapy,which considerably undermine the therapeutic outcomes for those with advanced lung cancer.Epithelial-mesenchymal transi-tion(EMT)serves as a crucial biological process closely associated with physiological or pathological processes such as tis-sue embryogenesis,organogenesis,wound repair,and tumor invasion.Numerous studies have indicated that EMT,mediated through various signaling pathways,plays a pivotal role in the initiation,progression,and metastasis of lung cancer,while it is also closely associated with drug resistance in lung cancer cells.Therefore,research focusing on the molecular mechanisms and pathophysiology related to EMT can contribute to reversing drug resistance in drug treatment for lung cancer,thereby improv-ing prognosis.This article reviews the progress in research on EMT in the invasion,metastasis,and drug resistance of lung can-cer based on relevant domestic and international literature.关键词
肺肿瘤/上皮间充质转化/侵袭/转移/耐药性Key words
Lung neoplasms/Epithelial-mesenchymal transition/Invasion/Metastasis/Drug resistance引用本文复制引用
孙恒星,熊梦婷,谢栓栓,温静..上皮间充质转化:肺癌侵袭转移及耐药性的生物学基础与临床展望[J].中国肺癌杂志,2025,28(2):155-164,10.基金项目
This paper was supported by the grant from National Natural Science Foundation of China(No.82272673)(to Sh-uanshuan XIE). 本文受国家自然科学基金项目(No.82272673)资助 （No.82272673）
