中国普通外科杂志2025，Vol.34Issue(2)：365-374,10.DOI:10.7659/j.issn.1005-6947.240671
胆道损伤修复机制及新型治疗策略
Mechanisms of bile duct injury repair and novel therapeutic strategies
摘要
Abstract
Bile duct injuries can be classified into iatrogenic and non-iatrogenic categories.Non-iatrogenic bile duct injuries include immune,infectious,vascular,ischemic,genetic,idiopathic,and neoplastic causes.After injury,the biliary epithelial cells undergo closely linked pathological processes,such as inflammatory repair,epithelial regeneration,and fibrous repair.These processes interact with inflammatory and stromal cells through autocrine and paracrine mechanisms,coordinating the repair process to maintain the structural and functional integrity of the bile ducts.In the absence of effective intervention,bile duct injuries can lead to bile leakage,biliary strictures,and even progress to cirrhosis,severely affecting the patient's quality of life.Currently,treating bile duct injuries is no longer limited to traditional surgical methods but also includes non-surgical treatments such as immune modulation,bile acid regulation,and gut microbiota adjustment.With the development of medical technology,novel treatments such as gene therapy,stem cell/organoid technology,and endoscopic retrograde cholangiopancreatography/tissue-engineered scaffolds are gaining attention and are expected to become effective treatment options for bile duct injuries in the future.This review focuses on the etiology and pathological mechanisms during the repair process of bile duct injuries and summarizes existing and potential treatment approaches,providing a reference for future research and clinical management of bile duct injuries.关键词
胆道疾病/基因编辑/类器官/组织工程/综述Key words
Biliary Tract Diseases/Gene Editing/Organoids/Tissue Engineering/Review分类
医药卫生引用本文复制引用
彭柏铭,向杨,张剑权..胆道损伤修复机制及新型治疗策略[J].中国普通外科杂志,2025,34(2):365-374,10.基金项目
国家自然科学基金资助项目(82260136) （82260136）
海南省科技厅院士创新平台科研专项基金资助项目(YSPTZX202027) （YSPTZX202027）
海口市重点科技创新基金资助项目(2022-032). （2022-032）
