中国比较医学杂志2025，Vol.35Issue(1)：163-171,9.DOI:10.3969/j.issn.1671-7856.2025.01.017
SHP2在结肠炎相关性结肠癌与结直肠癌发展中的作用及其作为治疗靶点的研究进展
Role of SHP2 in development of colitis-associated colon cancer and colorectal cancer and its potential as a therapeutic target
摘要
Abstract
Colorectal cancer(CRC)is one of the most common malignant life-threatening tumors,with serious impacts on patient quality of life.Src homology 2 domain-containing protein tyrosine phosphatase(SHP2)has recently become a hot topic in the field of cancer research,and has demonstrated a close relationship with CRC.SHP2,encoded by the PTPN11 gene,is a non-receptor tyrosine kinase commonly present in various tissues and cells of the human body.Existing research shows that SHP2 plays a crucial role in regulating CRC and colitis-associated colon cancer(CAC),and the emergence of SHP2 allosteric inhibitors has identified SHP2 as a potential new therapeutic target for patients with CRC.Here we review the structure of SHP2 and its roles in CRC and CAC.关键词
酪氨酸磷酸酶/SHP2/PTPN11/结直肠癌/结肠炎相关性结肠癌Key words
tyrosine phosphatase/SHP2,PTPN11/colorectal cancer/colitis-associated colon cancer分类
医药卫生引用本文复制引用
张昊,刁庆飞,樊建春,李萌,贾举名,杨春白雪,武雪亮..SHP2在结肠炎相关性结肠癌与结直肠癌发展中的作用及其作为治疗靶点的研究进展[J].中国比较医学杂志,2025,35(1):163-171,9.基金项目
2022年河北省自然科学精准医学联合基金培育项目(H2022405033). （H2022405033）
