中国药物经济学2025，Vol.20Issue(2)：85-88,98,5.DOI:10.12010/j.issn.1673-5846.2025.02.017
二代头孢联合氨甲环酸辅助膝关节单髁置换术对老年膝关节骨性关节炎的治疗效果
Therapeutic Effect of Second-generation Cephalosporin combined with Tranexamic Acid assisted Unicompartmental Knee Arthroplasty on Elderly Patients with Knee Osteoarthritis
徐宏伟 1朱宏刚 1武博1
作者信息
- 1. 辽健集团阜新矿总医院骨外科(关节与运动医学),辽宁 阜新 123000
- 折叠
摘要
Abstract
Objective To explore the therapeutic effect of second-generation cephalosporin combined with tranexamic acid assisted unicompartmental knee arthroplasty on elderly patients with knee osteoarthritis.Methods A total of 80 elderly patients with KOA admitted to Fuxin Mine General Hospital of Liaojian Group from August 2020 to August 2023 were randomly divided into tranexamic acid group and conventional group,with 40 cases each.All patients underwent knee unicondylar replacement.The conventional group received conventional anti-infection treatment with cefuroxime sodium after surgery,and the tranexamic acid group received intravenous tranexamic acid before or during skin resection on the basis of the control group,or intraarticular tranexamic acid after surgery.Postoperative blood loss,VAS score and length of stay,hemoglobin and coagulation function before and after operation,knee joint function,complication rate were compared between the two groups.Results There was no difference in VAS score between the two groups(P＞0.05).Tranexamic acid group had less blood loss and shorter hospital stay than the conventional group(P＜0.05).The levels of hemoglobin(Hb),partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)in the tranatemic acid group 1 week after surgery had no significant changes compared with those before surgery(P＞0.05).It was significantly lower in conventional group(P＜0.05),and higher in tranexamic acid group than in control group(P＜0.05).The knee joint score(HSS)in tranexamic acid group was higher than that in conventional group 1 week after surgery(P＜0.05).The incidence of postoperative hemorrhage,hematoma formation,postoperative infection and deep venous thrombosis in tranexamic acid group was lower than that in conventional group(P＜0.05).Conclusion Treating elderly patients with knee osteoarthritis with unicompartmental knee arthroplasty and adding cefoperazone combined with tranexamic acid as adjuvant therapy after surgery can reduce postoperative blood loss,shorten hospital stay,and improve hemoglobin reduction and coagulation dysfunction caused by excessive blood loss,improve recent knee joint function,and further reduce the incidence of postoperative complications in patients.关键词
头孢呋辛钠/氨甲环酸/膝关节单髁置换术/膝关节骨性关节炎/失血量/并发症Key words
Cefuroxime sodium/Tranexamic acid/Unicompartmental knee arthroplasty/Knee osteoarthritis/Blood loss/Complication分类
医药卫生引用本文复制引用
徐宏伟,朱宏刚,武博..二代头孢联合氨甲环酸辅助膝关节单髁置换术对老年膝关节骨性关节炎的治疗效果[J].中国药物经济学,2025,20(2):85-88,98,5.
