中国中西医结合影像学杂志2025，Vol.23Issue(2)：185-190,207,7.DOI:10.3969/j.issn.1672-0512.2025.02.010
基于fMRI探究针刺对无先兆偏头痛患者脑功能活动的影响
Exploring the effect of acupuncture on brain functional activity in migraine without aura based on fMRI technology
摘要
Abstract
Objective:To use fMRI and regional homogeneity(ReHo)analysis method to explore the effects and differences of true and sham acupuncture on brain function in patients with migraine without aura(MWoA).Methods:A total of 36 patients with MWoA were included in this study,randomly assigned to either true acupuncture(18 cases)or sham acupuncture(18 cases).All patients underwent fMRI scans before and after acupuncture,and the number of headache attacks,duration,work/learning incapacity duration,visual analogue scale(VAS),headache impact test-6(HIT-6)and migraine-specific questionnaire(MSQ)scores were recorded.Using ReHo's method for image data analysis,and extracting the differences in brain area values before and after acupuncture between the two groups for correlation analysis with clinical indicators.Results:In the true acupuncture group,the VAS,HIT-6,MSQ(Role Function-Restrictive,Role Function-Preventive,Emotional Function)scores,work/learning incapacity duration showed statistical differences before and after acupuncture(all P<0.05).In the sham acupuncture group,VAS,HIT-6 and MSQ(Role Function-Restrictive)scores showed statistical differences before and after acupuncture(all P<0.05).There were no statistically significant differences in clinical efficacy evaluation indicators between the two groups after acupuncture(all P>0.05).The true acupuncture group induced ReHo increases in right superior temporal gyrus,right precentral gyrus,and ReHo decreases in right middle frontal gyrus,right anterior cingulate cortex,left mid-cingulate cortex,right angular gyrus after acupuncture,while the sham acupuncture group reduced ReHo decrease in left parietal inferior gyrus.Correlation analysis showed that the ReHo changes of right anterior cingulate gyrus in the true acupuncture group before and after treatment were negatively correlated with VAS score changes(r=-0.57,P=0.02),while the ReHo changes in the sham acupuncture group were not correlated with clinical efficacy indicators(all P>0.05).Compared with the sham acupuncture group,the true acupuncture group induced ReHo increases in left posterior central gyrus,right middle occipital gyrus,left supraoccipital gyrus,left superior frontal gyrus,left precentral gyrus,right precentral gyrus,left paracentral lobule,and ReHo decreases in right infratemporal gyrus,right superior parietal gyrus,right inferior frontal gyrus after acupuncture.Conclusions:Both true and sham acupuncture improve VAS,HIT-6,and MSQ(Role Function-Restrictive)scores in MWoA patients,but the true acupuncture also improves work/learning incapacity duration,MSQ(Role Function-Preventive,Emotional Function)scores in MWoA patients.Changes in brain function in the middle frontal gyrus,anterior cingulate gyrus,and superior temporal gyrus may be the main central mechanism by which acupuncture modulates clinical symptoms in MWoA patients,and the inferior parietal gyrus may be a key brain region for the efficacy of comfort acupuncture for MWoA.关键词
针刺/磁共振成像/无先兆偏头痛/局部一致性Key words
Acupuncture/Magnetic resonance imaging/Migraine without aura/Regional homogeneity引用本文复制引用
高小雨,田甜,王潇,倪夕秀,欧阳旭,赵凌,董凌琳..基于fMRI探究针刺对无先兆偏头痛患者脑功能活动的影响[J].中国中西医结合影像学杂志,2025,23(2):185-190,207,7.基金项目
国家重点研发计划项目(2019YFC1709700) （2019YFC1709700）
四川省自然科学基金项目(2022NSFCS1493). （2022NSFCS1493）
