中国中西医结合影像学杂志2025，Vol.23Issue(2)：191-196,6.DOI:10.3969/j.issn.1672-0512.2025.02.011
新生儿缺氧缺血性脑病脑损伤的预测模型构建
Predictive modeling for brain injuries in neonatal hypoxic-ischemic encephalopathy
摘要
Abstract
Objective:To develop a predictive model for multiple brain injuries in neonates with hypoxic-ischemic encephalopathy(HIE).Methods:This retrospective study analyzed 319 HIE neonates,87 cases with multiple brain injuries and 232 cases without multiple injuries.Maternal and perinatal variables were assessed through univariate logistic regression screening,followed by multivariate logistic regression.A nomogram was constructed and evaluated for discrimination,calibration,and clinical utility.Results:Univariate logistic regression analysis showed that the intrauterine distress,Apgar score,birth weight,parity,and fetal position had statistical differences(all P<0.01).Multivariate logistic regression analysis confirmed intrauterine distress,Apgar score,birth weight,and parity as independent risk factors for brain injury(all P<0.05),which were used for modeling.The model predicted the differentiation of various brain injuries in HIE neonatus was good,with AUC of 0.827(95%CI 0.775-0.879),cut-off value of 0.24,sensitivity of 78.2%,specificity of 75.0%.The calibration curve showed that the risk predicted by the model was highly consistent with the actual situation(Hosmer-Lemeshow test,χ2=4.64,P=0.79).The decision curve showed that the model had clinical applicability.Conclusions:This perinatal parameter-based prediction model effectively stratifies multiple brain injury risk in HIE neonates,offering clinical references for early intervention planning.关键词
缺氧缺血,脑/婴儿,新生/脑损伤/预测模型Key words
Hypoxia-ischemia,brain/Infant,newborn/Brain injuries/Prediction model引用本文复制引用
李德欢,李栋学,龙宗敏,王雪,沈达梅,何青,王荣品..新生儿缺氧缺血性脑病脑损伤的预测模型构建[J].中国中西医结合影像学杂志,2025,23(2):191-196,6.基金项目
贵州省科技支撑计划项目(黔科合支撑[2019]2810号) （黔科合支撑[2019]2810号）
遵义市科技计划项目(遵市科合HZ字[2021]267号). （遵市科合HZ字[2021]267号）
