中国中西医结合影像学杂志2025，Vol.23Issue(2)：228-231,4.DOI:10.3969/j.issn.1672-0512.2025.02.018
冠状动脉CTA量化脂肪衰减指数指导冠状动脉非钙化斑块危险分层的价值
Quantitative fat attenuation index derived from coronary CTA for risk stratification of non-calcified coronary plaques
摘要
Abstract
Objective:To evaluate the clinical utility of coronary CTA-derived fat attenuation index(FAI)in risk stratification of non-calcified plaques.Methods:A total of 160 patients with non-calcified plaques identified by coronary CTA(non-calcified plaque group)and 50 controls without coronary lesions(control group)were enrolled.The non-calcified plaque group was further stratified by luminal stenosis severity into mild(72 cases),moderate(53 cases),and severe(35 cases)subgroups.FAI measurements were performed for all participants.The correlation between the luminal stenosis degree and FAI was analyzed,as well as the value of FAI in risk stratification of non-calcified plaques.Results:The non-calcified plaque group demonstrated significantly higher FAI compared to the control group(P<0.05).FAI had significant differences in mild,moderate,severe subgroups in the non-calcified plaque group(P<0.05).FAI in the mild subgroup was lower than that of the moderate and severe subgroups(bothe P<0.05),while no significant difference was found in FAI between the moderate subgroup and the severe subgroup(P>0.05).Pearson analysis revealed a positive correlation between FAI and luminal stenosis severity(r=0.523,P<0.05).The ROC curve indicated that the AUC,specificity and sensitivity of FAI in risk stratification of non-calcified plaques were 0.710,70.50%and 75.00%,respectively.Conclusions:Coronary CTA-derived FAI correlates positively with luminal stenosis severity in non-calcified plaques and shows clinically relevant utility for plaque risk stratification,serving as a promising quantitative biomarker for assessing coronary plaque progression and cardiovascular risk.关键词
冠状动脉/脂肪衰减指数/非钙化斑块/危险分层/体层摄影术,X线计算机Key words
Coronary artery/Fat attenuation index/Non-calcified plaque/Risk stratification/Tomography,X-ray computed引用本文复制引用
刘学谦,秦涛,丁倩倩..冠状动脉CTA量化脂肪衰减指数指导冠状动脉非钙化斑块危险分层的价值[J].中国中西医结合影像学杂志,2025,23(2):228-231,4.基金项目
2024年度河北省医学科学研究课题计划(20241033). （20241033）
