中国中药杂志2025，Vol.50Issue(5)：1155-1163,9.DOI:10.19540/j.cnki.cjcmm.20241215.105
灵芝酸及其衍生物的生物合成进展
Biosynthesis of ganoderic acid and its derivatives
摘要
Abstract
Ganoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species,and is one of the most important pharmacologically active components in G.lucidum,exhibiting antioxidant,anti-neuropsychiatric,anti-tumor,and immune-enhancing properties.The content of ganoderic acid in G.lucidum is very low,and the traditional extraction process is complex,yielding minimal amounts at high cost.The biosynthetic pathway of G.lucidum triterpenoids(GLTs),including the synthesis of different structural forms of ganoderic acid from lanosterol,as well as the molecular regulatory mechanisms involving key regulatory enzyme genes and their functions,are not yet fully understood.With the continuous development of synthetic biology technologies,there has been a deeper understanding of the biosynthesis and metabolic regulation pathways of ganoderic acid and its derivatives at the molecular level.Research has explored the key regulatory enzyme genes related to ganoderic acid biosynthesis and their functions.Moreover,through the optimization of synthetic biology and culture conditions,large-scale production and preparation of GLTs at the cellular level have been achieved.This paper reviews and analyzes the latest research progress on the biosynthesis pathways and metabolic regulation of GLTs,focusing on the configuration of ganoderic acid and its derivatives,the biosynthetic pathways,key enzyme genes,transcription factors related to ganoderic acid biosynthesis,signal transduction mechanisms,and factors affecting triterpenoid biotransformation.This review is expected to provide a theoretical basis and technical reference for improving the efficient production of triterpenoid pharmacological components and the exploitation and utilization of G.lucidum resources.关键词
灵芝/灵芝酸/生物合成/代谢调控Key words
Ganoderma lucidum/ganoderic acid/biosynthesis/metabolic regulation引用本文复制引用
宋鸿雁,杨湾,刘力维,程霞英,杨东风,杨宗岐..灵芝酸及其衍生物的生物合成进展[J].中国中药杂志,2025,50(5):1155-1163,9.基金项目
浙江省自然科学基金杭州区域创新发展联合基金项目(LHZSZ24H280003) （LHZSZ24H280003）
浙江理工大学绍兴生物医药研究院有限公司开放课题(SXAB202210) （SXAB202210）
