中国中药杂志2025，Vol.50Issue(5)：1209-1223,15.DOI:10.19540/j.cnki.cjcmm.20241115.301
牡蛎(近江牡蛎)药材、煅牡蛎饮片及其标准汤剂的物相变化及量质传递分析
Phase changes and quantity-quality transfer of raw material,calcined decoction pieces,and standard decoction of Ostreae Concha(Ostrea rivularis)
摘要
Abstract
The phase changes and quantity-quality transfer of 17 batches of Ostreae Concha(Ostrea rivularis)during the raw material-calcined decoction pieces-standard decoction process were analyzed.The content of calcium carbonate(CaCO3),the main component,was determined by chemical titration,and the extract yield and transfer rate were calculated.The CaCO3 content in the raw material,calcined decoction pieces,and standard decoction was 94.39%-98.80%,95.03%-99.22%,and 84.58%-90.47%,respectively.The process of raw material to calcined decoction pieces showed the yield range of 96.85%to 98.55%and the CaCO3 transfer rate range of 96.92%to 99.27%.The process of calcined decoction pieces to standard decoction showed the extract yield range of 2.86%to 5.48%and the CaCO3 transfer rate range of 2.59%to 5.13%.The results of X-ray fluorescence(XRF)assay showed that the raw material,calcined decoction pieces,and standard decoction mainly contained Ca,Na,Mg,Si,Br,Cl,Al,Fe,Cr,Mn,and K.The chemometric results showed an increase in the relative content of Cr,Fe,and Si from raw material to calcined decoction pieces and an increase in the relative content of Mg,Al,Br,K,Cl,and Na from calcined decoction pieces to standard decoction.X-ray diffraction(XRD)was employed to establish XRD characteristic patterns of the raw material,calcined decoction pieces,and standard decoction.The XRD results showed that the main phase of all three was calcite,and no transformation of crystalline form or generation of new phase was observed.Fourier transform infrared spectroscopy(FTIR)was employed to establish the FTIR characteristic spectra of the raw material,calcined decoction pieces,and standard decoction.The FTIR results showed that the raw material had internal vibrations of O-H,C-H,C=O,C-O,and CO2-3 groups.Due to the loss of organic matter components after calcination,no information about the vibrations of C-H,C=O,and C-O groups was observed in the spectra of calcined decoction pieces and standard decoction.In summary,this study elucidated the quantity-quality transfer and phase changes in the raw material-calcined decoction pieces-standard decoction process by determining the CaCO3 content,calculating the extract yield and transfer rate,and comparing the element changes,FTIR characteristic spectra,and XRD characteristic pattern.The results were reasonable and reliable,laying a foundation for the subsequent process research and quality control of the formula granules of calcined Ostreae Concha(O.rivularis Gould),and providing ideas and methods for the quality control of the whole process of raw material-decoction pieces-standard decoction-formula granules of Ostreae Concha and other testacean traditional Chinese medicine.关键词
牡蛎/标准汤剂/量质传递/物相变化/特征图谱/X射线荧光光谱/X射线衍射光谱/傅里叶变换红外光谱Key words
Ostreae Concha/standard decoction/quantity-quality transfer/phase changes/characteristic spectra/X-ray fluores-cence/X-ray diffraction/Fourier transform infrared spectroscopy引用本文复制引用
张洪怡,王福,胡媛,刘友平,陈士林,陈林,陈鸿平,周靖惟,刘佳雯,费文波,黄仕如,陈玉梅,李重阳,李菲菲,马巧伶..牡蛎(近江牡蛎)药材、煅牡蛎饮片及其标准汤剂的物相变化及量质传递分析[J].中国中药杂志,2025,50(5):1209-1223,15.基金项目
国家中医药管理局应用基础研究课题(gzyjc20210901) （gzyjc20210901）
