中国中药杂志2025，Vol.50Issue(6)：1449-1457,9.DOI:10.19540/j.cnki.cjcmm.20241213.601
丹酚酸B对冠状动脉粥样硬化性心脏病的作用机制研究进展
Research advances in mechanism of salvianolic acid B in treating coronary heart disease
摘要
Abstract
Coronary heart disease is a cardiovascular disease that affects coronary arteries.It presents high incidence and high mortality worldwide,bringing a serious threat to human health and quality of life.Salviae Miltiorrhizae Radix et Rhizoma derived from Salvia miltiorrhiza is widely used in the treatment of cardiovascular diseases,such as coronary heart disease.Salvianolic acid B is an active component in Salviae Miltiorrhizae Radix et Rhizoma extracts,and studies have shown that it has anti-inflammatory,antioxidant,apoptosis-and autophagy-regulating,anti-fibrosis,and metabolism-modulating effects.This article reviews the research progress regarding the therapeutic effect of salvianolic acid B on coronary heart disease in the recent decade.It elaborates on the role and mechanism of salvianolic acid B in treating coronary heart disease from multiple perspectives,such as the inhibition of thrombosis,improvement of blood circulation,reduction of myocardial cell injury,and inhibition of cardiac remodeling.This article provides a theoretical basis for the application of Chinese medicinal materials and TCM prescriptions containing salvianolic acid B in the treatment of coronary heart disease.关键词
丹酚酸B/丹参/冠心病/血栓/心肌损伤Key words
salvianolic acid B/Salviae Miltiorrhizae Radix et Rhizoma/coronary heart disease/thrombus/myocardial damage引用本文复制引用
曹洪鸣,孙晖,刘畅,闫广利,孔玲,韩莹,王喜军..丹酚酸B对冠状动脉粥样硬化性心脏病的作用机制研究进展[J].中国中药杂志,2025,50(6):1449-1457,9.基金项目
国家自然科学基金青年科学基金项目(82304709) （82304709）
