中国中药杂志2025，Vol.50Issue(6)：1458-1470,13.DOI:10.19540/j.cnki.cjcmm.20241214.201
附子化学成分与炮制工艺研究进展
Research progress in chemical constituents and processing methods of Aconiti Lateralis Radix Praeparata
摘要
Abstract
This article aims to study the processing methods by exploring the main chemical constituents of Aconiti Lateralis Radix Praeparata and the toxicity-attenuating mechanisms.The relevant articles were retrieved from multiple databases with the time interval of 1960-2024,and the chemical constituents of Aconiti Lateralis Radix Praeparata and the toxicity-attenuating mechanisms of its processing methods were summarized.The review revealed that the chemical constituents of Aconiti Lateralis Radix Praeparata included 32 diester-type alkaloids,36 monoester-type alkaloids,43 alkanolamine-type alkaloids,and 8 lipid-type alkaloids.At the same time,other chemical constituents such as water-soluble alkaloids were also studied,and their pharmacological activities were summarized.The toxicity-attenuating mechanisms of the processing methods included constituent loss,hydrolysis,ester exchange,and ion-pair action.The processing methods of Aconiti Lateralis Radix Praeparata have developed from being traditional to modern,with simplified operation and increased retention amounts of active constituents,which have improved the efficacy of processed Aconiti Lateralis Radix Praeparata products and have facilitated the industrial production.However,the existing processing methods of Aconiti Lateralis Radix Praeparata cannot completely solve the problem of possible reduction in efficacy during toxicity attenuation.More toxicity-attenuating mechanisms and lipid-type alkaloids of Aconiti Lateralis Radix Praeparata should be explored,which is expected to reduce its toxicity while retaining its efficacy.关键词
附子/炮制/双酯型生物碱/单酯型生物碱/脂型生物碱/减毒机制Key words
Aconiti Lateralis Radix Praeparata/processing/diester-type alkaloids/monoester-type alkaloids/lipid-type alkaloids/toxicity-attenuating mechanism引用本文复制引用
胡家豪,李文儒,时庆欣,宋成武..附子化学成分与炮制工艺研究进展[J].中国中药杂志,2025,50(6):1458-1470,13.基金项目
湖北省自然科学基金项目(2023AFD151) （2023AFD151）
