中国中药杂志2025，Vol.50Issue(6)：1496-1506,11.DOI:10.19540/j.cnki.cjcmm.20241224.501
中药对结直肠癌有氧糖酵解影响的研究进展
Research progress in effect of traditional Chinese medicine on aerobic glycolysis in colorectal cancer
摘要
Abstract
Colorectal cancer(CRC)is a common malignant tumor worldwide.Due to the treatment intolerance and side effects,CRC rank the top among various cancers regarding the incidence and mortality rates.Therefore,exploring new therapies is of great significance for the treatment of CRC.Aerobic glycolysis(AEG)plays an important role in the microenvironment formation,proliferation,metastasis,and recurrence of CRC and other tumor cells.It has been confirmed that intervening in the AEG pathway can effectively curb CRC.The active ingredients and compound prescriptions of traditional Chinese medicine(TCM)can effectively inhibit the proliferation,metastasis,and drug resistance and regulate the apoptosis of tumor cells by modulating AEG-associated transport proteins[eg,glucose transporters(GLUT)],key enzymes[hexokinase(HK)and phosphofructokinase(PFK)],key genes[hypoxia-inducible factor 1(HIF-1)and oncogene(c-Myc)],and signaling pathways(MET/PI3K/Akt/mTOR).Accordingly,they can treat CRC,reduce the recurrence,and improve the prognosis of CRC.Although AEG plays a key role in the development and progression of CRC,the specific mechanisms are not yet fully understood.Therefore,this article delves into the intrinsic connection of the targets and mechanisms of the AEG pathway with CRC from the perspective of tumor cell glycolysis and explores how active ingredients(oxymatrine,kaempferol,and dioscin)and compound prescriptions(Quxie Capsules,Jiedu Sangen Decoction,and Xianlian Jiedu Prescription)of TCM treat CRC by intervening in the AEG pathway.Additionally,this article explores the shortcomings in the current research,aiming to provide reliable targets and a theoretical basis for treating CRC with TCM.关键词
有氧糖酵解/结直肠癌/中药/综述Key words
aerobic glycolysis/colorectal cancer/traditional Chinese medicine/review引用本文复制引用
马旭,唐晓勇,李生龙,郑光荣,田大成,卢刚刚,高杰,安瑜琪,曹丽媛,李亮..中药对结直肠癌有氧糖酵解影响的研究进展[J].中国中药杂志,2025,50(6):1496-1506,11.基金项目
甘肃省自然科学基金项目(23JRRA1240,22JR5RA616) （23JRRA1240,22JR5RA616）
甘肃省卫生健康行业科研计划项目(GSWSKY2021-036) （GSWSKY2021-036）
甘肃省中医特色优势专科建设项目(甘卫中医函[2022]50号) （甘卫中医函[2022]50号）
甘肃省肠梗阻专科联盟建设项目(甘卫医政函[2021]132号) （甘卫医政函[2021]132号）
