摘要
Abstract
Objective:To observe the combined application effect of Methylprednisolone and bi-level non-invasive positive airway pressure(BiPAP)in the clinical treatment of severe respiratory failure.Method:A total of 82 patients with severe respiratory failure admitted to Huangling County People's Hospital from June 2022 to June 2023 were selected and randomly divided into two groups using the envelope method.Both groups received routine treatment,with the control group(36 cases)received BiPAP and the observation group(46 cases)received Methylprednisolone on the basis of the control group.The application effects of the two groups were compared.Result:The total effective rate,forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),arterial oxygen pressure(PaO2),arterial oxygen saturation(SaO2),and oxygenation index of the observation group were higher than those of the control group,and arterial carbon dioxide pressure(PaCO2),systolic blood pressure,diastolic blood pressure,heart rate,and levels of tumor necrosis factor-α(TNF-α),procalcitonin(PCT),and C-reactive protein(CRP)were lower than those of the control group,the differences were statistically significant(P<0.05).At the same time,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of conventional treatment for severe respiratory failure,the combined use of Methylprednisolone and BiPAP can significantly improve arterial blood gas indicators,enhance lung function,and alleviate respiratory inflammation,the treatment is safe and practical.关键词
甲泼尼龙/双水平气道无创正压通气/重症呼吸衰竭/肺功能/动脉血气指标/炎症因子Key words
Methylprednisolone/Bi-level non-invasive positive airway pressure ventilation/Severe respiratory failure/Lung function/Arterial blood gas indicators/Inflammatory factors
