遵义医科大学学报2025，Vol.48Issue(3)：274-279,285,7.
敏感肺结核患者强化期痰培养延迟阴转的危险因素分析
Analysis of risk factors for delayed negative conversion of sputum culture dur-ing intensive phase in patients with sensitive pulmonary tuberculosis
摘要
Abstract
Objective To explore the risk factors affecting the delayed negative conversion of sputum culture in patients with sensitive pulmonary tuberculosis(TB)during the intensive phase.Methods 567 pulmonary TB pa-tients diagnosed through sputum culture at Beijing Chest Hospital from June 2020 to June 2024 were included.They were divided into two groups based on the negative conversion of sputum culture at the end of the intensive phase:the negative conversion group and the non-negative conversion group.Logistic regression analysis was used to analyze the risk factors for delayed negative conversion of sputum culture during the intensive phase in patients.Results At the end of the intensive phase,there were 423 cases(74.6%)in the negative conversion group and 144 cases(25.4%)in the non-negative conversion group.Multivariate logistic regression analysis showed that age≥60 years[OR(95%CI):3.092(2.383 －4.947),P＝0.029],male[3.062(1.717 － 5.460),P＜0.001],smoking history[1.904(1.071 －3.386),P＝0.028],drinking history[1.934(1.095 －3.416),P＝0.023],diabetes[2.585(1.587 －4.209),P＜0.001],pulmonary cavity≥2[2.543(1.497 －4.321),P＝0.001],and affected lung fields≥4[3.880(1.614 －9.326),P＝0.002]were the risk factors for delayed negative conversion of sputum culture in intensive stage.Conclusion In clinic,corresponding meas-ures should be taken to intervene in patients with the above risk factors,and the duration of intensive treatment can be appropriately extended.关键词
肺结核/强化期/培养/危险因素Key words
pulmonary tuberculosis/intensive phase/culture/risk factors分类
医药卫生引用本文复制引用
史珂,代金芳,李强..敏感肺结核患者强化期痰培养延迟阴转的危险因素分析[J].遵义医科大学学报,2025,48(3):274-279,285,7.基金项目
北京市通州区第三批"两高"人才项目(NO:YHLJ202005). （NO:YHLJ202005）
