遵义医科大学学报2025，Vol.48Issue(3)：280-285,6.
预后营养指数和炎症指标与卒中后抑郁的相关性分析
Analysis of prognostic nutritional index and inflammatory indicators in relation to poststroke depression
摘要
Abstract
Objective To assess the correlation of the prognostic nutrition index(PNI)combined with inflam-matory indicators with post-stroke depression(PSD).Methods This study was a retrospective analysis of 328 stroke patients treated in the Department of Neurology of the First Affiliated Hospital of Harbin Medical University from January 2020 to January 2024.According to the stroke onset at 90 d the presence of PSD was divided into 112 cases(34.15%)in the PSD group and 216 cases(65.85%)in the non-PSD group.Independent risk fac-tors for PSD were analyzed using univariate and multivariate logistic regression,and the efficacy of PNI combined with inflammatory indexes in predicting PSD was assessed using ROC curves,with AUC as the main evaluation index.Results Univariate logistic regression showed that the differences in the levels of age,proportion of diabe-tes mellitus,per capita monthly household income,NIHSS score,platelets,IL-6,IL-8,NLR and PNI levels were statistically significant(P＜0.05).Multifactorial logistic regression showed that age(OR＝1.223,95%CI:1.034 －1.445),NIHSS score(OR＝1.767,95%CI:1.303 －2.395),IL-6(OR＝1.456,95%CI:1.097 －1.933)were independent risk factors for PSD,whereas PNI was its protective factor(OR＝0.619,95%CI:0.460 －0.832).The ROC curve showed that PNI combined with IL-6 predicted PSD with an AUC of 0.870(95%CI:0.831 －0.908),a sensitivity of 86.61%,and a specificity of 72.22%,which was superior to the predictive efficacy of a single indicator.Conclusion Both PNI and IL-6 are closely related to the occurrence of PSD,and their combined application can predict the risk of PSD early,thus assisting clinical early identification of PSD and early intervention.关键词
卒中/卒中后抑郁/预后营养指数/炎症指标Key words
stroke/post-stroke depression/prognostic nutritional index/inflammation indicator分类
医药卫生引用本文复制引用
马维丽,王恩石,高戴娜,关卓..预后营养指数和炎症指标与卒中后抑郁的相关性分析[J].遵义医科大学学报,2025,48(3):280-285,6.基金项目
黑龙江省卫生健康委基金资助项目(NO:2020－104). （NO:2020－104）
