遵义医科大学学报2025，Vol.48Issue(3)：318-324,7.
m6A甲基阅读蛋白YTHDF3调控肿瘤发生发展的研究进展
Research progress on m6 A methylation reader protein YTHDF3 and its regula-tion of cancer initiation and progression
摘要
Abstract
N6-methyladenosine(m6A)is the most prevalent post-transcriptional modification of RNA in eu-karyotic cells.As a crucial methyl reader protein involved in m6A modification,YTH N6-methyladenosine RNA binding protein F3(YTHDF3)can identify downstream target genes following m6A modification and participate in the regulation of gene expression.Current research suggests that YTHDF3 plays a pivotal role in the onset and progression of cancer,influencing cancer cell migration,epithelial-mesenchymal transition,and angiogenesis.YTHDF3 has the potential to emerge as a novel molecular target for cancer diagnosis and drug development,of-fering fresh insights and directions for tumor diagnosis and treatment.This article aims to comprehensively review the research advancements of YTHDF3 in cancer,presenting novel research concepts and treatment targets for the clinical investigation of m6A modification in cancer therapy.关键词
N6甲基腺苷化/YTH N6甲基腺苷RNA结合蛋白3/癌症治疗Key words
N6-methyladenosine/YTH N6-methyladenosine RNA binding protein F3/cancer treatment分类
医药卫生引用本文复制引用
黄悠阳,赵然尊..m6A甲基阅读蛋白YTHDF3调控肿瘤发生发展的研究进展[J].遵义医科大学学报,2025,48(3):318-324,7.基金项目
国家自然科学基金资助项目(NO:81960066). （NO:81960066）
