中药与临床2025，Vol.16Issue(2)：17-22,6.
黄芩苷-人参总皂苷纳米乳的制备及处方优化研究
Preparation and optimization of Baicalin-Total Ginsenoside Nanoemulsion
摘要
Abstract
Objective:To optimize the preparation process of Baicalin-Total Ginsenoside nanoemulsion using Box-Behnken design-effect surface method.Methods:Ultrasonic emulsification was used to prepare Baicalin-Total Ginsenoside nanoemulsion.Based on single-factor experiments,with oil phase amount,mixed emulsifier amount,and mixed emulsifier ratio as influencing factors,particle size,maximum loading capacity of baicalin,and maximum loading capacity of ginsenoside were used as evaluation indicators.After optimizing the preparation process using Box-Behnken design,the process was validated.Results:The optimal preparation conditions for the nanoemulsions included using 4.32%glyceryl caprylate/caprate,EL40 to PEG400 ratio of 3∶1,and 30%mixed emulsifier.Under these conditions,the particle size of Baicalin-Total Ginsenoside nanoemulsion was 46.25 nm,the maximum drug load of baicalin was 2.38 mg·g-1,and the maximum drug load of total ginsenoside was 28.25 mg·g-1.The product appeared as a pale yellow,clear liquid with good fluidity.Conclusion:The optimized Baicalin-Total Ginsenoside nanoemulsion are homogeneous and stable in particle size,high in drug loading,and stable in prescription process,which can provide a reference for the research and development of new dosage forms of related drugs.关键词
黄芩苷/人参总皂苷/纳米乳/超声乳化法/Box-Behnken设计-效应面法/工艺优化Key words
Baicalin/Total Ginsenoside/nanoemulsion/ultrasonic emulsification/Box-Behnken design response surface methodology/process optimization分类
医药卫生引用本文复制引用
邓婕,高乐莹,刘昊林,李楠,李晓秋,马茵,龙宇,吴媛媛,胡月,贺小方,冯慧意,吴欠欠..黄芩苷-人参总皂苷纳米乳的制备及处方优化研究[J].中药与临床,2025,16(2):17-22,6.基金项目
成都中医药大学青基进阶人才专项(QJJJ2022014) （QJJJ2022014）
成都中医药大学乡村振兴专项(XCZX2022007) （XCZX2022007）
四川省科学技术厅青年科学基金项目(2022NSFSC1406) （2022NSFSC1406）
