动物营养学报2025，Vol.37Issue(3)：1458-1469,12.DOI:10.12418/CJAN2025.125
嗜黏蛋白阿克曼菌对动物肠道屏障的影响及其作用机制
Effects of Akkermansia muciniphila on Animal Intestinal Barrier and Its Mechanism
摘要
Abstract
Akkermansia muciniphila(A.muciniphila)is a promising next-generation probiotics that has been shown to be closely associated with intestinal barrier homeostasis of host.Here we reviewed the biological prop-erties of A.muciniphila,its distribution in the gut,as well as its effects and mechanisms on the intestinal barri-er.A.muciniphila can participate in the regulation of the intestinal barrier through multiple pathways,including enhancing the tight junctions of intestinal epithelial cells(IECs),promoting the regeneration of IECs,facilita-ting the production of mucin and goblets to enhance the mucus barrier,inhibiting inflammatory responses,and influencing the gut microbiota.Future research needs to build different clinical models based on existing de-scriptive studies to elaborate in detail the molecular mechanisms of the interaction between A.muciniphila and host intestinal barrier,providing new directions for the study of intestinal health and the development of probi-otics.[Chinese Journal of Animal Nutrition,2025,37(3):1458-1469]关键词
嗜黏蛋白阿克曼菌/下一代益生菌/肠道屏障Key words
Akkermansia muciniphila/next-generation probiotics/intestinal barrier分类
畜牧业引用本文复制引用
刘燕娇,戴兆来,罗玉衡..嗜黏蛋白阿克曼菌对动物肠道屏障的影响及其作用机制[J].动物营养学报,2025,37(3):1458-1469,12.基金项目
国家自然科学基金面上项目(32372900) （32372900）
四川省自然科学基金面上项目(2023NSFSC0237) （2023NSFSC0237）
