动物营养学报2025，Vol.37Issue(3)：1480-1488,9.DOI:10.12418/CJAN2025.127
细胞焦亡在动物肠道炎症损伤中的作用机制研究
Study on Mechanism of Pyroptosis in Intestinal Inflammatory Injury in Animals
摘要
Abstract
The intestine is one of the primary immune organs in animal body.Intestinal inflammation is often accompanied by symptoms such as mucosal damage,increased intestinal wall permeability and diarrhea,and may be mediated by pyroptosis.Pyroptosis is a form of programmed cell death mediated by gasdermin protein and characterized by cell membrane pore formation,membrane rupture,cell swelling and release of cell con-tents.When the organism,s intestinal tract is disturbed by infectious and non-infectious factors,excessive cellu-lar pyroptosis may cause intestinal inflammation,leading to a variety of diseases.This review summarizes the signaling pathways of pyroptosis and its role in intestinal inflammatory injuries in animals aiming to provide ide-as for the treatment of intestinal inflammation.[Chinese Journal of Animal Nutrition,2025,37(3):1480-1488]关键词
细胞焦亡/肠道炎症/焦孔素/NLRP3Key words
pyroptosis/intestinal inflammation/gasdermin/NLRP3分类
农业科技引用本文复制引用
陈纪薇,王哲奇,高爱琴,徐元庆..细胞焦亡在动物肠道炎症损伤中的作用机制研究[J].动物营养学报,2025,37(3):1480-1488,9.基金项目
内蒙古自治区自然科学基金(2022QN03005,2023LHMS03064) （2022QN03005,2023LHMS03064）
内蒙古自治区直属高校基本科研业务费项目(BR220135,BR22-13-13) （BR220135,BR22-13-13）
内蒙古农业大学动物科学学院高水平成果培育专项(QT202214) （QT202214）
