动物营养学报2025，Vol.37Issue(3)：1575-1584,10.DOI:10.12418/CJAN2025.135
富马酸和肉桂醛及其联合添加对断奶仔猪生长性能、血清生化和抗氧化指标以及肠道炎症反应的影响
Effects of Fumaric Acid and Cinnamic Aldehyde and Their Combination on Growth Performance,Serum Biochemical and Antioxidant Indices and Intestinal Inflammatory Response of Weaned Piglets
摘要
Abstract
This experiment was conducted to investigate the effects of fumaric acid and cinnamic aldehyde and their combination on growth performance,serum biochemical and antioxidant indices and intestinal inflammato-ry response of weaned piglets.A total of 72"Duroc×Landrace×Yorkshine"crossbred weaned piglets(half male and half female)of 28-day-old with an initial body weight of(7.79±0.48)kg were randomly divided in-to 4 groups with 6 replicates per group and 3 pigs per replicate,and raised in individual pens.Piglets in the control group(CON group)were fed a basal diet,and others in the experimental groups were fed the basal di-et supplemented with 600 mg/kg fumaric acid(FA group),400 mg/kg cinnamic aldehyde(CA group)and 600 mg/kg fumaric acid+400 mg/kg cinnamic aldehyde(combined supplemental group,FC group),respec-tively.The experiment lasted for 28 days.At 08:00 on the day after the experiment,6 piglets in each group were injected with 200 μg/kg BW lipopolysaccharide(LPS)intraperitoneally.The results showed as follows:1)compared with CON group,the final body weight,average daily gain(ADG)and average daily feed in-take(ADFI)of weaned piglets in experimental groups were significantly increased(P＜0.05),and the ratio of feed to gain(F/G)was significantly decreased(P＜0.05).Meanwhile,the final body weight and ADG in FA and FC groups were significantly higher than those in CA group(P＜0.05).2)Compared with CON group,the serum malondialdehyde(MDA)content of weaned piglets in CA and FC groups was significantly de-creased(P＜0.05),and the serum catalase(CAT)activity was significantly increased(P＜0.05).Mean-while,the serum MDA content in FC group was significantly lower than that in FA and CA groups(P＜0.05),and the serum CAT activity was significantly higher than that in FA and CA groups(P＜0.05).3)Compared with CON group,the serum contents of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)of weaned piglets in experimental groups were significantly decreased(P＜0.05).Meanwhile,the serum TNF-α content in CA and FC groups was significantly lower than that in FA group(P＜0.05).4)Compared with CON+LPS group,the contents of TNF-α and IL-6 in jejunum of weaned piglets in experimental groups were significantly decreased(P＜0.05),and the interleukin-10(IL-10)content in jejunum was significantly increased(P＜0.05);the transforming growth factor-β(TGF-β)content in jejunum in FA+LPS group was significantly in-creased(P＜0.05).Meanwhile,the contents of TNF-α and IL-6 in jejunum in FC+LPS group were signifi-cantly lower than those in FA+LPS and CA+LPS groups(P＜0.05).5)Compared with CON+LPS group,the relative mRNA expression levels of Toll-like receptor 4(TLR4),nuclear factor-κB(NF-κB),TNF-α and IL-6 in jejunum of weaned piglets in experimental groups were significantly decreased(P＜0.05),and the mRNA relative expression levels of TGF-β and IL-10 in jejunum were significantly increased(P＜0.05).In conclu-sion,dietary supplementation of fumaric acid and cinnamic aldehyde alone or in combination can improve the growth performance,antioxidant function and anti-inflammatory ability of weaned piglets,and the combined supplementation has a synergistic effect.[Chinese Journal of Animal Nutrition,2025,37(3):1575-1584]关键词
富马酸/肉桂醛/断奶仔猪/生长性能/抗氧化/炎症反应Key words
fumaric acid/cinnamic aldehyde/weaned piglets/growth performance/antioxidant/inflammato-ry response分类
农业科技引用本文复制引用
刘禹彤,杨冠华,王璐瑶,马欣怡,乔家运,李海花..富马酸和肉桂醛及其联合添加对断奶仔猪生长性能、血清生化和抗氧化指标以及肠道炎症反应的影响[J].动物营养学报,2025,37(3):1575-1584,10.基金项目
天津市"131"创新型人才团队(20180338) （20180338）
