大学化学2025，Vol.40Issue(2)：306-311,6.DOI:10.12461/PKU.DXHX202405118
铜/氧气催化合成非对称尿素类化合物实验设计
Experimental Design for the Copper/Dioxygen-Catalyzed Synthesis of Asymmetric Urea Derivatives
摘要
Abstract
The copper/dioxygen catalyzed radical reactions that features high reaction efficiency,mild reaction conditions,good functional group compatibility and environmental friendliness,has been widely applied in organic synthesis.Inspired by the principles of green and sustainable development and drawing on our recent research findings,we designed a comprehensive experiment for the copper/dioxygen-catalyzed cleavage of C―C bonds in amides to synthesize asymmetric urea derivatives at room temperature.This experiment features readily accessible starting materials,mild reaction conditions,ease of execution,and does not require complex instrumentation.It effectively fosters students'innovative abilities while providing insights into the forefront of radical chemistry.Consequently,this experiment holds significant practical and educational value.关键词
铜催化/酰胺C―C键断裂/尿素类化合物/有机化学实验Key words
Copper catalysis/C―C bond cleavage of amides/Urea derivatives/Organic chemistry laboratory分类
社会科学引用本文复制引用
白朝鲁门,包永胜..铜/氧气催化合成非对称尿素类化合物实验设计[J].大学化学,2025,40(2):306-311,6.基金项目
国家自然科学基金面上项目(22261044) （22261044）
