大学化学2025，Vol.40Issue(2)：332-340,9.DOI:10.12461/PKU.DXHX202405126
"在水上"无催化剂Mukaiyama-aldol反应合成3-二氟烷基-3-羟基氧化吲哚
"On Water"Catalyst-Free Mukaiyama-Aldol Reaction towards 3-Difluoroalkyl 3-Hydroxyloxindole
摘要
Abstract
This study presents an innovative teaching approach that integrates cutting-edge research into the organic chemistry curriculum through a"task-driven"group-based inquiry model.The focus is on the environmentally friendly"on water"strategy,demonstrating a catalyst-free Mukaiyama-aldol reaction between 1-methylisatin and difluoroenoxysilane,utilizing water as the solvent.This approach efficiently constructs 3-difluoroalkyl-3-hydroxyoxindole,a high-value compound.Four comparative control experiments were conducted by student groups,using common organic solvents(dichloromethane,toluene,methanol)alongside water.The results helped students independently assess the advantages of water as a solvent in organic reactions,challenging the traditional reliance on organic solvents.This pedagogical method avoids passive,lecture-based teaching,combining theoretical understanding with hands-on experimentation to deepen students'comprehension of green chemistry and frontier research in organic chemistry.The integration of foundational knowledge,scientific inquiry,and professional chemical skills represents a successful strategy for fostering high-quality talent in chemistry.关键词
任务驱动/小组合作/3-二氟烷基-3-羟基氧化吲哚/"在水上"反应Key words
Task driven/Group cooperation/3-Difluoroalkyl-3-hydroxyloxindole/"On water"reaction分类
社会科学引用本文复制引用
张梦瑶,苟星烨,黄友,刘慧娟,余金生.."在水上"无催化剂Mukaiyama-aldol反应合成3-二氟烷基-3-羟基氧化吲哚[J].大学化学,2025,40(2):332-340,9.基金项目
国家自然科学基金(22171087) （22171087）
