大学化学2025，Vol.40Issue(2)：341-347,7.DOI:10.12461/PKU.DXHX202405152
稀土金属催化糠醛合成环戊-2-烯酮衍生物的本科实验设计
Design of an Undergraduate Experiment on the Synthesis of Cyclopent-2-enone Derivatives Catalyzed by Rare Earth Metals
摘要
Abstract
This paper presents the design of an undergraduate experiment utilizing the rare-earth catalyst ErCl3∙6H2O to promote the one-step synthesis of cyclopent-2-enone derivatives.This reaction involves the biomass platform compound furfural and the commodity chemical dibenzylamine,proceeding via a Nazarov reaction and 4π-electrocyclization to afford important synthon cyclopentyl-2-enone derivatives in high yield.The experiment consists of four main stages:synthesis,filtration,recrystallization,and characterization.The project is characterized by its mild reaction conditions,non-toxic reagents,straightforward operation,good reproducibility,short reaction time,and high product yield,ideal for undergraduate laboratory courses.Furthermore,the experiment introduces important concepts such as green chemistry,high-value transformation of biomass platform compounds,and the theme of rare-earth metal catalysis.This project not only enriches the undergraduate experiment course,but also enhances the students'interest and accomplishment in chemistry.关键词
绿色化学/稀土金属催化/三氯化铒/生物质资源/糠醛Key words
Green chemistry/Rare earth metal catalysis/Erbium(Ⅲ)chloride/Biomass resources/Furfural分类
教育学引用本文复制引用
冯梦霞,李小洪,胡建强,黄良斌..稀土金属催化糠醛合成环戊-2-烯酮衍生物的本科实验设计[J].大学化学,2025,40(2):341-347,7.基金项目
华南理工大学教学成果奖培育项目(K524188016) （K524188016）
