大学化学2025，Vol.40Issue(2)：371-377,7.DOI:10.12461/PKU.DXHX202405187
可见光催化合成二氟甲基化咖啡因
Visible Light-Catalyzed Synthesis of Difluoromethylated Caffeine
摘要
Abstract
Visible light catalysis offers several advantages,including mild reaction conditions,high efficiency,low energy consumption,and broad functional group compatibility,making it a powerful tool in synthetic chemistry.Nitrogen-containing heterocyclic frameworks and fluorinated functional groups are widely present in bioactive molecules.Selectively introducing a difluoromethyl group(CF2H)into nitrogen heterocycles can significantly influence the pharmacological and pharmacokinetic properties of lead drug candidates.This paper reports a visible light-mediated radical difluoromethylation of caffeine,employing[bis(difluoroacetoxy)iodo]benzene as the difluoromethylating reagent.The reaction proceeds without the need for transition metals or oxidants,is straightforward to perform,and easy for students to learn,offering both educational and practical value.关键词
可见光催化/咖啡因/自由基反应/二氟甲基化Key words
Visible light catalysis/Caffeine/Radical reaction/Difluoromethylation分类
社会科学引用本文复制引用
朱丛军,张师杰,郭涛,袁金伟..可见光催化合成二氟甲基化咖啡因[J].大学化学,2025,40(2):371-377,7.基金项目
河南工业大学青年骨干教师培育计划 （）
河南省本科高校"化学专业核心课程思政教学团队"项目 （）
河南工业大学化学化工学院教育教学改革研究与实践项目 （）
