大学化学2025，Vol.40Issue(3)：342-348,7.DOI:10.12461/PKU.DXHX202405181
综合有机化学实验:磷钨酸催化三苯甲醇的直接转化制备肟醚类化合物
Comprehensive Organic Chemistry Experiment:Phosphotungstic Acid-Catalyzed Direct Conversion of Triphenylmethanol for the Synthesis of Oxime Ethers
摘要
Abstract
This study introduces a novel and environmentally friendly organic chemistry experiment that integrates cutting-edge research into academic practice.The experiment involves the direct conversion of triphenylmethanol to oxime ethers,catalyzed by phosphotungstic acid,a green solid acid,with dimethyl carbonate serving as a sustainable solvent.At room temperature,triphenylmethanol reacts with benzophenone oxime to yield oxime ethers and water.The influence of catalyst concentration on the reaction yield is systematically examined.Furthermore,the reaction mechanism—specifically,a nucleophilic substitution proceeding through a carbocation intermediate—is inferred based on catalytic conversion verification and UV spectroscopic analysis.This experiment offers several advantages,including green chemistry principles,mild reaction conditions,and relevance to current research.It enhances students'experimental competencies,fosters environmental awareness,and sparks interest in scientific research and innovation,making it highly suitable for university-level instruction.关键词
醇的直接转化/绿色化学/磷钨酸/亲核取代反应Key words
Direct conversion of alcohols/Green chemistry/Phosphotungstic acid/Nucleophilic substitution reaction分类
社会科学引用本文复制引用
韩峰,万福贤,李映,张丛丛,张元红,苗成霞..综合有机化学实验:磷钨酸催化三苯甲醇的直接转化制备肟醚类化合物[J].大学化学,2025,40(3):342-348,7.基金项目
山东省研究生优质课程项目(SDYKC2023032) （SDYKC2023032）
山东省研究生优质专业学位教学案例库项目(SDYAL2023040) （SDYAL2023040）
山东农业大学研究生教育质量提升计划(2022SZ002) （2022SZ002）
山东化学教指委项目(SDHX-YB-2022-15) （SDHX-YB-2022-15）
