肝胆胰外科杂志2025，Vol.37Issue(3)：185-190,6.DOI:10.11952/j.issn.1007-1954.2025.03.008
Callispheres载药微球急诊介入治疗肝细胞癌破裂出血的疗效分析
Short-and medium-term effects of Callispheres drug-eluting beads in the emergency intervention of ruptured hepatocellular carcinoma
摘要
Abstract
Objective To investigate the safety and short-to mid-term clinical efficacy of Callispheres drug-eluting beads during transcatheter arterial chemoembolization(TACE)for the emergency treatment of ruptured hepatocellular carcinoma(rHCC).Methods A total of 60 rHCC patients who underwent emergency interventional treatment at the First People's Hospital of Lianyungang between Jun.2018 and Jun.2023 were retrospectively included.Of these,36 patients received Callispheres drug-eluting beads as the primary embolic material(the experimental group),while 24 patients received gelatin sponge particles(the control group).The interventional treatment success rate,complication incidence rate,objective response rate(CR+PR),and disease control rate(CR+PR+SD)were compared between the two groups.Survival analysis was performed with Kaplan-Meier method to compare the median progression-free survival(mPFS)and the median overall survival(mOS)between the groups.Results The interventional treatment success rate was 100%in both groups and the postoperative complication incidence rates showed no significant statistical difference between the two groups(P>0.05).The objective response rates at 1,3,6,and 12 months post-treatment in the experimental group were 83.3%,80%,65.6%,and 45.8%,respectively,compared to 75.0%,72.7%,62.5%,and 36.4%for the control group.The disease control at 1,3,6,and 12 months post-treatment in the experimental group were 97.2%,85.7%,87.5%,and 58.3%,respectively,compared to 87.5%,81.8%,81.3%,and 54.5%in the control group.The experimental group had significantly longer mPFS(9 months vs 6.5 months,χ2=8.126,P=0.004)and mOS(14 months vs 9 months,χ2=7.688,P=0.006)than those in the control group.Conclusion For treatment of rHCC,Callispheres drug-eluting beads as the primary embolic material in TACE is safe and effective,with satisfactory short-to mid-term clinical efficacy.However,further multi-center and large sample studies are needed to confirm the long-term clinical efficacy.关键词
肝细胞癌/破裂出血/肝动脉化疗栓塞/Callispheres载药微球/明胶海绵颗粒Key words
hepatocellular carcinoma/rupture and bleeding/transcatheter arterial chemoembolization/Callispheres drug-eluting beads/gelfoam particles分类
临床医学引用本文复制引用
石大群,刘飞,曹刚,张根山,徐文杰,刘金,刘书屹..Callispheres载药微球急诊介入治疗肝细胞癌破裂出血的疗效分析[J].肝胆胰外科杂志,2025,37(3):185-190,6.基金项目
江苏省研究型医院学会转化基金专项资助项目(2024-GDZXKT-01-07) （2024-GDZXKT-01-07）
连云港市肿瘤防治科技发展计划项目(QN202302) （QN202302）
连云港市第一人民医院青年英才项目(QN2214). （QN2214）
