临床与病理杂志2024，Vol.44Issue(12)：1703-1711,9.DOI:10.11817/j.issn.2095-6959.2024.240853
基于组蛋白修饰探讨中医药在抗抑郁中的作用
Research progress in the role of traditional Chinese medicine in antidepressant therapy based on histone modifications
摘要
Abstract
Depression ranks first among global psychiatric disorders in terms of incidence.Although its etiology and pathogenesis remain unclear,the prevailing view suggests that genetic variations and environmental factors are the main contributors to the development and progression of depression.Histone modifications,as a key mechanism of epigenetic regulation,influence gene transcription and play a role in both physiological and pathological processes of living organisms.Traditional Chinese medicine can effectively participate in the treatment of depression by modulating histone modifications such as acetylation,phosphorylation,and ubiquitination.These studies not only reveal the underlying mechanisms of traditional Chinese medicine in depression treatment but also provide a reference for the future development of antidepressant therapies and drug discovery based on traditional Chinese medicine.关键词
组蛋白修饰/抑郁症/中医药/乙酰化/磷酸化/泛素化Key words
histone modification/depression/traditional Chinese medicine/acetylation/phosphorylation/ubiquitination分类
医药卫生引用本文复制引用
王添,刘金雨,张紫萦,曹雪,姜波..基于组蛋白修饰探讨中医药在抗抑郁中的作用[J].临床与病理杂志,2024,44(12):1703-1711,9.基金项目
黑龙江省自然科学基金(PL2024H21) （PL2024H21）
黑龙江省中医药科研项目(ZHY2024028) （ZHY2024028）
黑龙江省卫生健康委员会科研课题(20222121020662).This work was supported by the Natural Science Foundation of Heilongjiang Province(PL2024H21) （20222121020662）
the Heilongjiang Province Traditional Chinese Medicine Research Project(ZHY2024028) （ZHY2024028）
the Scientific Research Project of Health Commission of Heilongjiang Province(20222121020662),China. （20222121020662）
