海南医科大学学报2025，Vol.31Issue(6)：457-462,6.DOI:10.13210/j.cnki.jhmu.20241213.001
MMP-3在中枢神经系统疾病中的应用
Applications of MMP-3 in central nervous system Diseases
摘要
Abstract
Matrix metallopeptidase 3(MMP-3)has a wide range of biological functions in the central nervous system(CNS),particularly playing a key role in injury repair and the development of neuropathological diseases.MMP-3 promotes axo-nal and myelin regeneration by degrading extracellular matrix(ECM)components and inhibiting nerve regeneration inhibitors.Ad-ditionally,MMP-3 regulates blood-brain barrier(BBB)permeability and modulates neuroinflammation,contributing to the patho-logical processes of neurodegenerative diseases such as Parkinson's disease(PD)and Alzheimer's disease(AD).Notably,abnor-mal MMP-3 expression is closely related to the invasiveness and malignancy of brain tumors.This review summarizes the mecha-nisms by which MMP-3 operates in these CNS diseases and discusses its potential as a therapeutic target.Future research should focus on in-depth analysis of the molecular regulatory mechanisms of MMP-3 to advance the development of targeted therapeutic strategies and improve treatment outcomes for related diseases.关键词
MMP-3/中枢神经系统/帕金森病/阿尔茨海默症/胶质母细胞瘤Key words
MMP-3/Central nervous system/Parkinson's disease/Alzheimer's disease/Glioblastoma分类
临床医学引用本文复制引用
钱牧,刘运运,祝毓帅,冯基高,张帆,赵建农..MMP-3在中枢神经系统疾病中的应用[J].海南医科大学学报,2025,31(6):457-462,6.基金项目
This study was supported by Research and Application of Key Technologies for Prevention,Treatment and Emergency First Aid of Cardiovascular and Cerebrovascular Diseases in Hainan Province(ZDKJ202004) 海南省心脑血管疾病防治及急诊急救关键技术研究与应用(ZDKJ202004) （ZDKJ202004）
