华西口腔医学杂志2025，Vol.43Issue(2)：190-196,7.DOI:10.7518/hxkq.2025.2024288
正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究
Relationship between fluid shear stress in alveolar bone under orthodontic forces and bone remodeling rate
摘要
Abstract
Objective This study explores the differences in fluid flow within alveolar cancellous bone at various sites under orthodontic forces and elucidates the relationship between fluid shear stress and bone remodeling.These fin-dings lay the groundwork for understanding the biomechanical mechanisms of orthodontic tooth movement.Methods Stress relaxation tests were performed on human alveolar bone samples to determine material parameters by using the Prony series.An inverse model of alveolar bone was then developed for numerical simulations of fluid-struc-ture interactions to calculate fluid flow within cancellous bone.Meanwhile,a rat model of tooth movement was es-tablished to investigate variations in bone remodeling speeds across different regions.Results The microstructural distribution of cancellous alveolar bone was similar in hu-mans and rats.The bone volume fraction and trabecular thickness gradually decreased from root cervical region to root apical region,while the trabecular space gradually increased.Under the influence of orthodontic forces,fluid shear stress within cancellous bone showed spatial variability across different levels,with the highest shear stress occurring at the root apical region,ranging from 0 to 0.936 6 Pa.Additionally,the rat model of tooth movement indicated that bone re-modeling occurred more rapidly at the root apical region.Conclusion Fluid stimulation has a remarkable effect on al-veolar bone remodeling,causing changes in the structure of alveolar bone and ultimately regulating the speed of structu-ral remodeling.关键词
牙槽骨/流固耦合/流体剪切力/多孔结构Key words
alveolar bone/fluid-structure interaction/fluid shear stress/porous structure分类
口腔医学引用本文复制引用
吴斌,胡可欣,杨帆,卢轶,姜迪,易扬,严斌..正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究[J].华西口腔医学杂志,2025,43(2):190-196,7.基金项目
National Natural Science Foundation of China(82071143,51305208) （82071143,51305208）
Key Research and Development Program of Jiangsu Province(BE2022795) （BE2022795）
Key Medical Research Projects of Jiangsu Health Commission(ZDA202003) （ZDA202003）
Jiangsu Provincial Key Laboratory of Oral Diseases Research Fund(JSKLOD-KF-1901) 国家自然科学基金(82071143,51305208) （JSKLOD-KF-1901）
江苏省重点研发计划(BE2022795) （BE2022795）
江苏省卫生健康委员会重点医学研究项目(ZDA202003) （ZDA202003）
江苏省口腔疾病研究重点实验室研究基金(JSKLOD-KF-1901) （JSKLOD-KF-1901）
