解剖学杂志2025，Vol.48Issue(1)：60-64,5.DOI:10.3969/j.issn.1001-1633.2025.01.011
蛋白质精氨酸甲基转移酶6在炎症相关疾病中的研究进展
Research progress of protein arginine methyltransferase 6 in inflammation-related diseases
摘要
Abstract
Protein arginine methyltransferase 6(PRMT6)is one of the type Ⅰ PRMT family members which catalyzes the monomethylation and asymmetric dimethylation of arginine residues on protein substrates.It has a catalytic structure that is not completely identical to other type Ⅰ PRMT family members,and exhibits differences in catalytic substrates.An increasing number of studies have reported that PRMT6 not only plays an important role in the tumor process,but also serves as a regulator in the inflammatory process.This article aims to review the catalytic structure and function of PRMT6,as well as the research progress on its role in both anti-inflammatory and pro-inflammatory responses in organs.关键词
甲基转移酶/蛋白质精氨酸甲基转移酶6/炎症Key words
methyltransferase/protein arginine methyltransferase 6/inflammation分类
基础医学引用本文复制引用
黄智道,黎力,沃吟晴,韩超峰,孙琳琳,熊俊..蛋白质精氨酸甲基转移酶6在炎症相关疾病中的研究进展[J].解剖学杂志,2025,48(1):60-64,5.基金项目
国家自然科学基金(32170878) （32170878）
上海市自然科学基金(20ZR1451600) （20ZR1451600）
上海市卫生和健康委员会科研项目(201940439) （201940439）
