机器人外科学杂志（中英文）2025，Vol.6Issue(3)：464-470,7.DOI:10.12180/j.issn.2096-7721.2025.03.022
机器人辅助宫颈癌根治术后基线NLR、PLR与尿路感染的关系及其风险预测研究
Relationship between baseline NLR,PLR and urinary tract infection after robot-assisted radical surgery for cervical cancer and its risk prediction
摘要
Abstract
Objective:To investigate the relationship between baseline neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and urinary tract infection(UTI)after robot-assisted radical cervical cancer surgery,and to develop a risk prediction model for UTI.Methods:A total of 100 patients who underwent robot-assisted radical cervical cancer surgery at our center from August 2021 to August 2024 were enrolled.They were divided into the UTI group(n=29)and the non-UTI group(n=71)based on whether postoperative UTI occurred or not.Differences in postoperative baseline NLR and PLR levels between the two groups were compared.Binary Logistic regression analysis was performed to identify risk factors for UTI.Receiver operating characteristic(ROC)curves were constructed to assess the predictive efficacy of NLR,PLR,and their combination for UTI.Results:Postoperative baseline NLR and PLR levels were significantly higher in the UTI group than those in the non-UTI group(P<0.05).Postoperative urinary retention,prolonged catheterization time,elevated baseline NLR,and elevated PLR were identified as independent risk factors for UTI(P<0.05).A nomogram model for UTI risk prediction was constructed based on these factors.ROC analysis showed that the AUC values for NLR,PLR,their combination,and the nomogram model in predicting UTI were 0.827,0.794,0.920,and 0.981,respectively.DeLong's test revealed that the combined AUC was significantly higher than those of individual markers(P<0.05),and the nomogram model's AUC was significantly higher than those of NLR,PLR,and their combination(P<0.05).At the optimal cut-off value,the combined markers achieved a sensitivity and specificity of 0.828 and 0.944,respectively,while the nomogram model achieved 0.931 and 0.958.Internal validation confirmed the nomogram model's stability and positive net benefit.Conclusion:Elevated postoperative baseline NLR and PLR are risk factors for UTI after robot-assisted radical cervical cancer surgery.A nomogram model incorporating NLR,PLR,postoperative urinary retention,and catheterization time can effectively predict UTI risk in clinical practice.关键词
宫颈癌根治术/机器人辅助手术/腹腔镜手术/尿路感染/风险预测模型Key words
Radical Hysterectomy/Robot-assisted Surgery/Laparoscopic Surgery/Urinary Tract Infection/Risk Prediction Model分类
医药卫生引用本文复制引用
方前进,桑琳,王润秋,王青元..机器人辅助宫颈癌根治术后基线NLR、PLR与尿路感染的关系及其风险预测研究[J].机器人外科学杂志（中英文）,2025,6(3):464-470,7.基金项目
安徽省临床医学研究转化专项科研项目(202304295107020093) （202304295107020093）
2022年度安徽省妇幼保健协会"母婴营养与健康研究项目"(JKZD202206)Anhui Provincal Clinical Medical Research Transformation Project(202304295107020093) （JKZD202206）
Maternal and Child Nutrition and Health Research Project of Anhui Maternal and Child Health Care Association in 2022(JKZD202206) （JKZD202206）
