西南医科大学学报2025，Vol.48Issue(2)：116-123,8.DOI:10.3969/j.issn.2096-3351.2025.02.002
铁死亡和氧化应激在多发性骨髓瘤中相互作用的研究进展
Crosstalk between Ferroptosis and Oxidative Stress in Multiple Myeloma
摘要
Abstract
Ferropotsis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperox-ides to lethal levels,which is distinct from any known programmed cell death in the biological processes and morphological characteris-tics.The ferroptosis is correlated with numerous metabolic pathways,including iron homeostasis,lipid metabolism,and redox homeo-stasis,associating with the occurrence and treatment of hematological malignancies.Oxidative stress is a state of imbalance between oxidation and antioxidation,producing excessive levels of ROS,which can lead to deranged control of cellular functions and is also an important factor in tumor development.Ferroptosis pathway is associated with oxidative metabolism,and ROS not only participates in the regulation of ferroptosis and aslo play a key role in it.Whereas,the occurrence of ferroptosis will inevitably lead to lipid peroxida-tion.This article systematically summarizes the roles of iron death and oxidative stress in the development,progression,and treatment of multiple myeloma,with a view to providing new strategies for the treatment of multiple myeloma and overcoming drug resistance.关键词
铁死亡/氧化应激/多发性骨髓瘤/蛋白酶体抑制剂Key words
Ferroptosis/Oxidative stress/Multiple myeloma/Proteasome inhibitors分类
临床医学引用本文复制引用
刘家希,刘睿,吕杨,缪吉玉,何爱丽..铁死亡和氧化应激在多发性骨髓瘤中相互作用的研究进展[J].西南医科大学学报,2025,48(2):116-123,8.基金项目
国家自然科学基金(82370204) （82370204）
