摘要
Abstract
Objective:To investigate the effect of Labetalol combined with Nifedipine Sustained-Release Tablets in the treatment of hypertension during pregnancy(HDP).Methods:A total of 86 HDP patients admitted to Liaocheng Dongchangfu Maternal and Child Health Hospital from September 2021 to November 2023 were selected as the study objects and were divided into a control group and a study group according to random number table method,with 43 cases in each group.The control group was treated with Labetalol,and the study group was treated with Nifedipine Sustained-Release Tablets on this basis.Both groups we no tiveated 7 d.The therapeutic effect,blood pressure levels,umbilical artery hemodynamics,serological indexes and occurrence of adverse reactions of the two groups were compared.Results:The total effective rate of the study group was 95.35%,which was higher than 81.40%of the control group,the difference was statistically significant(P<0.05).After treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the study group were(129.57±7.45)mmHg and(85.36±6.81)mmHg,respectively,which were lower than(141.37±8.92)mmHg and(96.28±8.02)mmHg of the control group,the differences were statistically significant(P<0.05).After treatment,the plasma viscosity,peak velocity ratio of umbilical artery SBP to DBP,resistance index and hematocrit in the study group were(2.86±0.43)mPa·s,(1.67±0.20)%,(0.29±0.08)%and(32.22±3.57)%,respectively,which were lower than(3.39±0.51)mPa·s,(2.01±0.37)%,(0.37±0.10)%and(37.44±4.19)%in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein and homocysteine in the study group were(10.13±1.44)μmmol/L and(6.27±1.18)mg/L,respectively,which were lower than(13.22±2.53)μmmol/L and(8.03±1.37)mg/L in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 4.65%,which was lower than 9.30%in the control group,but there was no statistical significance between the two groups(P>0.05).Conclusion:Labetalol combined with nifedipine sustained-release Tablets can better control the blood pressure of HDP patients,improve their umbilical artery hemodynamics and serological indexes,and is safe and effective.关键词
妊娠期高血压/拉贝洛尔/硝苯地平缓释片/治疗效果/血压/脐动脉血流动力学Key words
Hypertension during pregnancy/Labetalol/Nifedipine Sustained-Release Tablets/Therapeutic effect/Blood pressure/Umbilical artery hemodynamics分类
医药卫生
