肿瘤预防与治疗2025，Vol.38Issue(3)：182-190,9.DOI:10.3969/j.issn.1674-0904.2025.03.002
呼吸门控结合Bodyfix固定装置立体定向放疗治疗肺寡转移肿瘤的临床疗效观察
Clinical Efficacy of Respiratory Gating Combined with Bodyfix Immobi-lization Device in Stereotactic Radiotherapy for Pulmonary Oligometastatic Tumors
摘要
Abstract
Objective:To treat patients with pulmonary ol-igometastasis using respiratory gating combined with the Body-fix fixation device,and to evaluate the clinical efficacy of ster-eotactic body radiation therapy(SBRT)as well as the inci-dence of radiation-induced toxicity.Methods:A retrospective analysis was conducted on 34 patients with pulmonary oligo-metastases treated using respiratory gating combined with the Bodyfix fixation device at our hospital between September 2019 and January 2023.A total of 66 lesions were treated with SBRT.Kaplan-Meier method and SPSS software were used to cal-culate the local control rate(LCR),progression-free survival rate(PFS)and overall survival rate(OS).Log-rank method and Cox models were performed to analyze prognostic factors associated with clinical efficacy.The occurrence of radioactive damage was observed and counted.Results:The median age of the included patients was 53 years(ranging from 30 to 70),the median follow-up time was 15.5 months(ranging from 12 to 47 months).The 1-and 2-year LCRs were 88.2％and 84.4％,respectively.The 1-and 2-year PFS rates were 70.6％and 54.1％,respectively.The 1-and 2-year OS rates were 97％and 97％,respectively.Whether to receive chemotherapy and immunotherapy concurrently with SBRT,as well as the presence of extrapulmonary metastases before treatment,were factors affecting progression-free survival(P＜0.05).Most of the enrolled patients experienced grade 0-2 radiation injuries without obvious clinical manifestations,and only one patient de-veloped grade 3 radiation pneumonitis.Conclusion:SBRT combined with respiratory gating and Bodyfix immobilization dem-onstrates favorable clinical efficacy and a lower incidence of radiation-induced injuries in patients with pulmonary oligometas-tases.Systemic therapy and the presence or absence of extrapulmonary metastases are closely associated with tumor progres-sion and may serve as important predictive factors.关键词
肺寡转移/立体定向放射治疗/呼吸门控/临床疗效Key words
Pulmonary oligometastasis/Stereotactic radiotherapy/Respiratory gating/Clinical efficacy分类
医药卫生引用本文复制引用
龙霞,罗明焱,麻佳慧,徐鹏,秦远,刘敏,张鹏,郎锦义..呼吸门控结合Bodyfix固定装置立体定向放疗治疗肺寡转移肿瘤的临床疗效观察[J].肿瘤预防与治疗,2025,38(3):182-190,9.基金项目
中华国际医学交流基金会肿瘤精准放疗星火计划临床科研基金项目(编号:2019-N-11-24) This study was supported by grants from China International Medical Foundation(No.2019-N-11-24). （编号:2019-N-11-24）
