世界中西医结合杂志2025，Vol.20Issue(2)：326-332,7.DOI:10.13935/j.cnki.sjzx.250219
绝经后女性骨质疏松临床预测模型构建及中西医预防分析
Construction of a Clinical Prediction Model for Postmenopausal Osteoporosis and A-nalysis of TCM and Western Medicine Prevention
摘要
Abstract
Objective To analyze the risk factors for postmenopausal osteoporosis(PMOP)and explore the pre-vention strategy that integrates traditional Chinese medicine(TCM)and Western medicine by constructing a clinical predic-tion model.Methods A retrospective analysis was performed to obtain clinical data of 676 postmenopausal women who underwent physical examinations at Henan Provincial Orthopedic Hospital between May 2023 and May 2024,This included demographic data of the participants and measurements such as total procollagen type1 intact N-terminal propeptide(TP1NP),β-collagen carboxyl-terminal peptide(β-CTx),N-MID fragment of osteocalcin(NMID),parathyroid hor-mone(PTH),25-hydroxyvitamin D(25(OH)D),6-meter walk speed,five-time chair stand tests,grip strength,waist-to-hip ratio(WHR),and basal metabolic rate(BMR).Risk factors for osteoporosis in high-risk populations were sta-tistically analyzed and thoroughly verified.A clinical analysis of risk factors was conducted by integrating TCM and Western medicine based on the literature.Results Through univariate logistic regression analysis,it was found that age,height,weight,grip strength grading,a 6-meter walking speed of＞3.21 m/s,and a five-time chair stand test time of＞6.27 s were all risk factors for PMOP.Additionally,TP1 NP of＞59.18 pg/L,β-CTx of＞0.50 ng/mL,and PTH of＞26.44 pg/ml were also risk factors for PMOP(P＜0.05).A multivariate logistic regression analysis revealed that NMID,WHR,β-CTx of＞0.50 ng/mL,PTH of＞26.44 pg/ml,five-time chair stand test time of＞6.27 s,and SMI of＞6.07 kg/m2 were independent risk factors for PMOP(P＜0.05).In the evaluation of the nomogram prediction model,the validation group(AUC＞0.85)and training group(AUC＞0.85)showed good calibration performance.The combination of TCM and western medicine can give a more comprehensive understanding of the mechanism of PMOP.Conclusion By using demo-graphic and laboratory data,independent risk factors for PMOP can be screened,and clinical prediction models can be con-structed,helping improve the cost-effectiveness and efficacy of PMOP disease prevention.The integration of TCM and Western medicine better satisfies the community's needs for PMOP disease prevention.关键词
绝经后骨质疏松症/临床预测模型/高危因素/中西医结合预防策略Key words
Postmenopausal Osteoporosis/Clinical Prediction Model/High Risk Factor/Integrated Prevention Strategy of TCM and Western Medicine分类
医药卫生引用本文复制引用
刘林云,李小玲,王传珍,滕军燕,张迪,张文明,曹向阳..绝经后女性骨质疏松临床预测模型构建及中西医预防分析[J].世界中西医结合杂志,2025,20(2):326-332,7.基金项目
河南省科技攻关项目(242102310272) （242102310272）
河南省中医药科学研究专项(2024ZY3066)(2022ZY1116) （2024ZY3066）
