沈阳医学院学报2025，Vol.27Issue(2)：160-167,8.DOI:10.16753/j.cnki.1008-2344.2025.02.009
不同类型茶摄入与COVID-19感染风险之间的关系:一项基于双样本孟德尔随机化研究
Association between different types of tea intake and risk of COVID-19 infection:a two-sample Mendelian randomization study
摘要
Abstract
Objective:To investigate the relationship between different types of tea intake and COVID-19 infection.Methods:Data were retrieved from a genome-wide association study(GWAS),involving 447 485,and 64 949 people for single nucleotide polymorphisms(SNPs).Two-sample Mendelian randomization(MR)analysis was used to investigate the relationship of different types of tea intake with four subgroups of COVID-19 infected population,including COVID-19 infected population versus general population,COVID-19 hospitalized population versus general population,COVID-19 hospitalized population versus non-hospitalized population,and very severe respiratory confirmed population versus general population.Inverse-variance weighted(IVW)method was used as the main method of causal analysis.MR Egger intercept was used for pleiotropy test,and Cochran's Q-statistic was used for heterogeneity test.Results:Compared to the general population,tea intake decreased the incidence of COVID-19 in the infection population(IVW method,OR=0.806,95%CI:0.651-0.999),and the hospitalized population(IVW method,OR=0.533,95%CI:0.369-0.770).Additionally,the underlying pleiotropy was not found following the MR-Egger regression intercept(MR intercept=-0.002,P=0.667),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=52.712,P=0.057).Compared to the general population,the underlying pleiotropy in the hospitalized patients was not found by MR-Egger regression intercept(MR intercept=-0.001,P=0.909),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=25.214,P=0.945).However,green tea and herbal tea had no effect on COVID-19 infection.Conclusions:Overall tea intake reduces the risk of COVID-19 infection in the general population compared to COVID-19 infected and hospitalized populations,while green tea and herbal tea have no protective effect against COVID-19 infection.关键词
茶摄入/COVID-19/感染/两样本/孟德尔随机化研究Key words
tea intake/covid-19/infection/two sample/mendelian randomization study分类
中医学引用本文复制引用
王聪智,王敏,鲍丙宏,张子悦,赵康,张雨露,杨柳,张林,张冬梅,李晓萍..不同类型茶摄入与COVID-19感染风险之间的关系:一项基于双样本孟德尔随机化研究[J].沈阳医学院学报,2025,27(2):160-167,8.基金项目
2024年度校级重点科研基金项目(No.WK2024SZD03) （No.WK2024SZD03）
2020年度省级大学生创新创业计划项目(No.S202010368023) （No.S202010368023）
2023年度省级大学生创新创业计划项目(No.S202310368040) （No.S202310368040）
2024年度省级和国家级大学生创新创业计划项目(No.S202410368044 （）
No.202410368044) （）
