时珍国医国药2025，Vol.36Issue(4)：666-676,11.DOI:10.70976/j.1008-0805.SZGYGY-2025-0410
双柏散糊剂的制备工艺及质量控制
Preparation technique and quality control of Shuangbai Powder Paste
摘要
Abstract
Objective To investigate the preparation technique and quality control of Shuangbai Powder(SBP)paste,providing a refer-ence for the preservation and clinical application of this medicine.Methods SBP paste was prepared with different excipients(water,ginger juice,honey water,sugar water,vinegar water),under different light conditions(protected from light or not),and at different temperatures(low temperature and room temperature).The properties of the paste were observed,and the contents of isoquercitrin,ber-berine,luteolin,and emodin in SBP paste were determined by High performance liquid chromatography(HPLC).Results When the ra-tio of SBP to excipient was 5:11,the paste was formed with moderate humidity.The paste could be stored for only 3 days at room temper-ature,and 7 days at low temperature.With prolonged storage,the contents of isoquercitrin,berberine and luteolin in the paste were de-creased to varying degrees,while the content of emodin was increased.More active ingredients could be retained without avoiding light preservation,and cold storage slowed down the rate of change in active ingredients.When SBP used vinegar water as excipient,the over-all content of active ingredients was relatively higher remained during storage.Conclusion It is recommended that vinegar water be used as excipient in the clinical preparation of SBP paste and be stored under the refrigerated conditions.关键词
双柏散/糊剂/制备工艺/质量控制/高效液相色谱Key words
Shuangbai Powder/Paste/Preparation technique/Quality control/High performance liquid chromatography分类
医药卫生引用本文复制引用
覃滢颖,陈海辉,蓝鲜艳..双柏散糊剂的制备工艺及质量控制[J].时珍国医国药,2025,36(4):666-676,11.基金项目
国家自然科学基金地区科学基金项目(82260504) （82260504）
广西自然科学基金项目(2020GXNSFBA297112) （2020GXNSFBA297112）
柳州市科技局资助项目(2019DH10604) （2019DH10604）
