现代医药卫生2025，Vol.41Issue(3)：584-587,593,5.DOI:10.3969/j.issn.1009-5519.2025.03.002
ICU呼吸机相关性肺炎合并碳青霉烯类耐药鲍曼不动杆菌及肺炎克雷伯菌感染的一般特征分析
General characteristics analysis of ICU ventilator-associated pneumonia complicated with carbapenem resistant Acinetobacter baumannii and carbapenem resistant Klebsiella pneumoniae infections
摘要
Abstract
Objective To analyze the clinical characteristics and pathogenic differences between ventila-tor-associated pneumonia(VAP)and non-VAP patients in the intensive care unit(ICU),and explore the characteristics of VAP related drug-resistant bacterial infections.Methods A total of 288 patients who were admitted to the ICU of Changshou District People's Hospital in Chongqing for mechanical ventilation through-out 2023 were included in the study cohort.Among them,70 patients had positive respiratory pathogen culture and were diagnosed with pneumonia.According to the relationship between the results of the first pathogen test after mechanical ventilation and the start time of mechanical ventilation,they were divided into VAP co-hort(31 cases)and non-VAP cohort(39 cases).Retrospective collection of general information,vital signs,clinical features,pathogen characteristics,and drug resistance status of the included samples through an elec-tronic medical record system,and comparative analysis.Results The number of patients in the VAP cohort receiving combined antibiotic treatment was significantly lower than those in the non-VAP cohort.Age,respir-atory rate,and ICU mortality rate were significantly higher than those in the non-VAP cohort,and the differ-ences were statistically significant(P<0.05).The infection strains of VAP queue patients are mainly Acine-tobacter baumannii and Klebsiella pneumoniae,among which there are 7 cases of carbapenem resistant Acine-tobacter baumannii and 6 cases of carbapenem resistant Klebsiella pneumoniae.The non-VAP queue is mainly infected with Acinetobacter baumannii and fungi.Conclusion Advanced age and lack of combined antibiotic treatment are risk factors for VAP in ICU patients,who may experience clinical symptoms of increased respir-atory rate and increased ICU mortality.VAP combined with drug-resistant bacteria(carbapenem resistant Acinetobacter baumannii and carbapenem resistant Klebsiella pneumoniae)infection will bring more serious adverse prognosis.关键词
呼吸机相关性肺炎/重症监护病房/鲍曼不动杆菌/肺炎克雷伯菌/细菌感染/细菌抗药性Key words
Ventilator-associated pneumonia/Intensive care unit/Acinetobacter baumannii/Klebsiella pneumoniae/Bacterial infection/Bacterial drug resistance分类
临床医学引用本文复制引用
余锋,夏吉林,刘建..ICU呼吸机相关性肺炎合并碳青霉烯类耐药鲍曼不动杆菌及肺炎克雷伯菌感染的一般特征分析[J].现代医药卫生,2025,41(3):584-587,593,5.基金项目
重庆市科卫联合医学科研项目(2022MSXM113、2022QNXM010). （2022MSXM113、2022QNXM010）
