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REV-ERBs对头颈鳞状细胞癌的肿瘤调节作用

胡仿玲桂誉淋

现代医药卫生2025，Vol.41Issue(3)：594-598,5.

现代医药卫生2025，Vol.41Issue(3)：594-598,5.DOI:10.3969/j.issn.1009-5519.2025.03.004

REV-ERBs对头颈鳞状细胞癌的肿瘤调节作用

Tumor regulatory effect of REV-ERBs on head and neck squamous cell carcinoma

胡仿玲 ¹桂誉淋²

作者信息

1. 临沂市妇幼保健院耳鼻咽喉头颈外科,山东临沂 276000
2. 九江市第一人民医院耳鼻咽喉头颈外科,江西九江 332000
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摘要

Abstract

Objective To explore the tumor regulatory effect of circadian nuclear receptors,REV-ERBs,on head and neck squamous cell carcinoma(HNSCC).Methods In May 2020,CCK-8 assay,clone for-mation assay,Transwell assay and cell scratch assay were used to detect the effects of REV-ERBs specific re-ceptor agonist-SR9009 on cell proliferation,migration and invasion of HNSCC.The inhibitory effect of SR9009 on HNSCC was detected by in vitro drug sensitivity.Results SR9009 can significantly inhibit the proliferation,migration and invasion of HNSCC cells,and had a tumor suppressive effect on HNSCC.Conclusion SR9009,a spe-cific receptor agonist of REV-ERBs,has a tumor suppressive effect on HNSCC,which can be achieved through the regulation of REV-ERBs.

关键词

头颈鳞状细胞癌/REV-ERBs/SR9009/肿瘤抑制

Key words

Head and neck squamous cell carcinoma/REV-ERBs/SR9009/Tumor suppression

分类

临床医学

引用本文复制引用

胡仿玲,桂誉淋..REV-ERBs对头颈鳞状细胞癌的肿瘤调节作用[J].现代医药卫生,2025,41(3):594-598,5.

现代医药卫生

ISSN：1009-5519

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