现代医药卫生2025，Vol.41Issue(3)：604-607,4.DOI:10.3969/j.issn.1009-5519.2025.03.006
黄芩素、小檗碱、大黄酸、大黄素联合阿莫西林对幽门螺杆菌诱导GES-1分泌IL-8的影响
Effects of baicalin,berberine,rhein,emodin combined with amoxicillin on expressions of IL-8 in GES-1 cells with Helicobacter pylori infection
摘要
Abstract
Objective To study the effect of baicalin,berberine,rhein and emodin combined with amoxi-cillin(AMC)on expressions of Inter leukin-8(IL-8)in GES-1 cells with the treatment of Helicobacter pylori(Hp)infection.Methods The protocol was designed by ELISA methods,determined the expressions of IL-8 in GES-1 cells pretreated with baicalin,berberine,rhein,emodin and combined with AMC against Hp infection in October,2022.Results Baicalin,berberine,rhein and emodin could reduce the expressions of IL-8.Rhein,emodin combined with AMC could reduce the expressions of IL-8(P<0.05).In the study,emodin combined with AMC has the strongest effect on the inhibition of IL-8 secretion in GES-1 cells.There was no significant difference between baicalein combined with AMC,compared with AMC alone(P>0.05).Conclusion Berber-ine and emodin can significantly increase the anti-Hp activity of AMC by decreasing the secretion of IL-8 in GES-1 cells.However,baicalin and rhein could not increase the anti-Hp activity of AMC by decreasing the se-cretion of IL-8.关键词
黄芩素/小檗碱/大黄酸/大黄素/阿莫西林/幽门螺杆菌/胃上皮细胞/白细胞介素-8Key words
Baicalin/Berberine/Rhein/Emodin/Amoxicillin/Helicobacter pylori/Gastric epithelial cell/Interleukin-8分类
中医学引用本文复制引用
彭洁,唐芳..黄芩素、小檗碱、大黄酸、大黄素联合阿莫西林对幽门螺杆菌诱导GES-1分泌IL-8的影响[J].现代医药卫生,2025,41(3):604-607,4.基金项目
江西省中医药管理局科技计划项目(2022B1081). （2022B1081）
