现代医药卫生2025，Vol.41Issue(3)：612-615,4.DOI:10.3969/j.issn.1009-5519.2025.03.008
舌下特异性免疫治疗对变应性鼻炎患者临床疗效及呼出气一氧化氮水平的影响
Effects of sublingual specific immunotherapy on clinical efficacy and exhaled nitric oxide levels in patients with allergic rhinitis
摘要
Abstract
Objective To evaluate the effects of sublingual specific immunotherapy(SLIT)on the clini-cal efficacy and exhaled nitric oxide(NO)levels in patients with allergic rhinitis(AR).Methods A total of 114 AR patients admitted to the hospital from December 2021 to December 2023 were selected as the research objects,and they were divided into the observation group(76 cases)and the control group(38 cases).The pa-tients in the control group were treated with conventional antiallergic drugs,and the patients in the observa-tion group were treated with antiallergic drugs combined with SLIT.The total nasal symptom score(TNSS),total medication score(TMS),visual analogue scale(VAS)score,nasal exhaled nitric oxide(nNO),fractional exhaled nitric oxide(FeNO),concentration of alveolar nitric oxide(CaNO)and rhinoconjunctivitis quality of life questionnaire(RQLQ)were compared between the two groups before and after treatment.Results After one year of treatment,the levels of nNO and FeNO in the observation group[(496.85±260.62)ppb and(28.59±25.34)ppb]were significantly lower than those in the control group[(503.32±179.91)ppb and(31.26±21.95)ppb],and the differences were statistically significant(P<0.05).After one year of treat-ment,the scores of TNSS,TMS and VAS in the observation group[(0.72±0.74),(0.37±0.59),(0.72±1.23)points]were significantly lower than those in the control group[(3.39±1.05),(1.63±1.10),(3.08±1.19)points],and the differences were statistically significant(P<0.05).After one year of treatment,the RQLQ scores of patients in the observation group were significantly lower than those in the control group in seven aspects,and the differences were statistically significant(P<0.05).Conclusion SLIT combined drug therapy for AR resulted in better clinical outcomes and quality of life in patients,and improved nNO and FeNO levels.关键词
舌下特异性免疫治疗/变应性鼻炎/临床疗效/一氧化氮Key words
Sublingual specific immunotherapy/Allergic rhinitis/Clinical efficacy/Nitric oxide分类
临床医学引用本文复制引用
陈丽鸿,江洪,龙宇,蒋凤,刘成刚..舌下特异性免疫治疗对变应性鼻炎患者临床疗效及呼出气一氧化氮水平的影响[J].现代医药卫生,2025,41(3):612-615,4.基金项目
重庆市永川区自然科学基金计划项目(2023yc-jckx20029) （2023yc-jckx20029）
重庆医科大学附属永川医院科研课题资助项目(YJLC202113). （YJLC202113）
